CHICAGO—ACR Convergence 2025 featured a diverse and influential body of research advancing the field of rheumatology. Abstracts and presentations with a focus on rheumatoid arthritis (RA) spanned the disease continuum. This synopsis highlights key areas from the meeting, including strategies to delay or prevent RA, emerging mechanisms of action in RA treatment, and the growing role of artificial intelligence (AI) and digital interventions in advancing RA research and clinical care.