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Jeffrey E. Barrick on Muck Rack

Jeffrey E. Barrick

As seen in: Nature, PLOS Biology, PLOS ONE, PNAS, ACS Publications, BioRxiv, ASM Journals
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Articles

Phage-encoded contingency loci enable bet-hedging against host defence mechanisms

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By Jasper B. Gomez, Jeffrey E. Barrick, Christopher Waters
| Nature Verified
Abstract Bacteriophages are the most diverse biological entities on Earth, but the processes influencing the evolution of genomic diversity in phages are poorly understood. Here, we show that phage genomes contain contingency loci, hypermutable DNA regions that promote reversible frameshift mutations through DNA polymerase slippage on simple sequence repeats. Contingency loci have been extensively described in bacteria, archaea and eukaryotes, yet are understudied in phages.
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Genetic Biosensor for Optimizing Double-Stranded RNA Production by Bacteria Click to copy article link Article link copied!

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By Lucio Navarro-Escalante, Anthony J. VanDieren, Jeffrey E. Barrick
| ACS Publications
Several methods have been developed to detect and visualize double-stranded RNA (dsRNA) in cells and tissues, including immunofluorescence assays and the use of dsRNA-binding domains fused to fluorescent proteins. (1−3) These tools have been primarily designed to detect viral dsRNA molecules in eukaryotic cells for studying and diagnosing infections of mammalian and plant viruses. (4,5) They are not suitable for the in vivo quantification of dsRNA molecules in prokaryotic cells.
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Symbiotic bacteria produce non-lytic vesicles with nucleic acid cargo

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By Nurila Kambar, Yulin Song, Carmen Herrera, Sean Leonard, Jeffrey E. Barrick, M. Stephen Trent, Nancy Moran, Cecilia Gontijo Leal, Cecília G. Leal, Max Baliga
| Nature Verified
Abstract Symbiotic bacteria in the gut have an important physiological impact on their hosts, but the mechanisms that underlie the exchange of molecular signals remain poorly understood. Membrane vesicles have been suggested to mediate the direct exchange of cytoplasmic content like nucleic acids (NAs), but their study is complicated by conflicting and imprecise reports of their type and composition.
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