Jennifer Hamilton

Abstract Engineered T cells, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR), have transformed cancer treatment and are being explored as therapeutics for autoimmune and infectious diseases. Enhancing T cell function through genome editing, either by disrupting endogenous genes or precisely inserting DNA payloads, has shown considerable promise1. However, the ex vivo manufacturing process is lengthy and costly, limiting accessibility of these therapies.

Abstract Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing cells like neurons, which must withstand decades of DNA damage without replicating. This lack of knowledge limits the efficiency and precision of genome editing in clinically relevant cells.

Punks (of the 70s and 80s kind) were not known for their optimism. Quite the opposite in fact. Raging against the establishment in various ways, there was “no future” because, according to the Sex Pistols, punks are “the poison / In your human machine / We’re the future / Your future”. To be punk, was, by definition, to resist the future.