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Jenying Deng on Muck Rack

Jenying Deng

As seen in: Cancer Discovery, Texas Medical Center
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Articles

3D Imaging Analysis on an Organoid-Based Platform Guides Personalized Treatment in Pancreatic Ductal Adenocarcinoma

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By Jenying Deng, Jianhua Ling, Xinqun Li, Ya'an Kang
| Texas Medical Center
Abstract BACKGROUNDPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches to assay patient tumors before treatment and identify effective treatment regimens based on tumor sensitivities are lacking.
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3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma

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By Jenying Deng, Jianhua Ling, Xinqun Li, Ya’an Kang
| The Journal of Clinical Investigation
Abstract BACKGROUND. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches to assay patient tumors before treatment and identify effective treatment regimens based on tumor sensitivities are lacking. We developed an organoid-based platform (OBP) to visually quantify patient-derived organoid (PDO) responses to drug treatments and associated tumor-stroma modulation for personalized PDAC therapy. METHODS.
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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis

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By Michael Kim, Xinqun Li, Jenying Deng, Yun Zhang
| Cancer Discovery Verified
Research Articles Michael P. Kim, Xinqun Li, Jenying Deng, Yun Zhang, Bingbing Dai, Kendra L. Allton, Tara G. Hughes, Christian Siangco, Jithesh J. Augustine, Ya'an Kang, Joy M. McDaniel, Shunbin Xiong, Eugene J. Koay, Florencia McAllister, Christopher A. Bristow, Timothy P. Heffernan, Anirban Maitra, Bin Liu, Michelle C. Barton, Amanda R. Wasylishen, Jason B. Fleming and Guillermina Lozano DOI: 10.1158/2159-8290.CD-20-1228 Published August 2021 This article requires a subscription to view the full text.
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