Jeong Kyeong Lee on Muck Rack

Jeong Kyeong Lee

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Oxidative photocatalysis on membranes triggers non-canonical pyroptosis - Nature Communications

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By Chaiheon Lee, Mingyu Park, Seungjin Na, Eunhye Hwang, James Vince, Duyoung Min, Gwangsu Yoon, Jeong Kyeong Lee
| Nature Verified
Abstract Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focused oxidative stress remains elusive. Herein, we report an amphiphilic photocatalyst localised in intracellular membranes to damage membrane proteins oxidatively, resulting in non-canonical pyroptosis.
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