Jerry Edward Chipuk

Abstract Mitochondria maintain a distinct biochemical environment that cooperates with pro-apoptotic BAX and BH3‑only proteins (e.g., BIM) to promote mitochondrial outer membrane permeabilization (MOMP), the key event to initiate physiological and pharmacological forms of apoptosis. The sphingosine-1-phosphate metabolite 2-trans-hexadecenal (2t‑hexadecenal) is a bioactive lipid that supports BAX-dependent MOMP.

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES , , , , , , , , , , , , , , , , , , , … (2011). Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: Roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell, 20(4), 524–537. https://doi.org/10.1016/j.ccr.2011.09.006 , , , , & (2016). Liver glucose metabolism in humans. Bioscience Reports, 36(6), 1–15. https://doi.org/10.1042/bsr20160385 , , & (2002).

Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with predicting potential pathways of resistance. A new analytical method for evaluating chemogenetic profiles reveals contributions from death-regulatory genes.