Jessica Barizzi

Abstract Regulatory factor X 7 (RFX7) nonsense mutations have been found in different human B cell malignancies. We therefore set out to study the role of RFX7 in B cell activation and lymphomagenesis. Here we show that RFX7 truncations cause loss-of-function and dominant-negative effects. Moreover, low RFX7 mRNA levels correlate with worse diffuse large B cell lymphoma prognosis.

Branchial cleft cysts are congenital anomalies derived from the branchial apparatus, most commonly presenting as lateral neck masses. Intrathyroidal localization is exceedingly rare and may mimic malignancy both radiologically and cytologically—particularly when squamous cells are identified and misinterpreted as malignant. Surgical resection is often required to achieve a definitive diagnosis.

Summary Background Pancreatic cancer is an aggressive malignancy and a leading cause of cancer death worldwide; its lethality is partly linked to the difficulty of early diagnosis. Modern devices for endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) were recently developed to improve targeting and sampling of small lesions, but innovative technologies for microscopic assessment are still lacking.