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Articles

Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression

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By Kaitlin Morse, Barker Hall, Sarah Swerdlow, Jessica Leslie
| Cell Press Verified
Highlights • Unbiased genetic approach reveals a role for yeast Swi/Snf in promoter repression • Swi/Snf represses promoters subject to upstream transcriptional readthrough • Repression is associated with Swi/Snf-dependent nucleosome remodeling • Swi/Snf-dependent repression regulates protein levels for LUTI-regulated genes Summary Alternative transcription start sites can affect transcript isoform diversity and translation levels.
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