Ji-Liang Lin on Muck Rack

Ji-Liang Lin

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Articles

BTAF1: a key regulator of DNA end resection and predictor of chemotherapy sensitivity in gastric cancer

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By Juan-Juan Xie, Xiao-Xia Cai, Run-Cong Nie, Peng Lin, Yi-Xin Yin, Jin-Ling Duan, Dan Xie, Mu-Yan Cai, Ji-Liang Lin, Zhi-Cheng Xiang, Chun-Hua Qu
| Nature Verified
Abstract BTAF1, an ATP-dependent remodeler of the TBP-DNA complex, is frequently mutated in gastric cancer. However, its role in DNA repair and therapeutic relevance remains largely undefined. Here, we show that BTAF1 knockout leads to accumulation of double-strand breaks (DSBs) by impairing DNA end-resection process of homologous recombination (HR) repair, thereby sensitizing cells to genotoxic agents both in vitro and in vivo.
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