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CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host–pathogen interactions
CD-CODE 2.0 (https://cd-code.org) is an enhanced web application and database of condensates, expanding the utility of version 1.0 for biomedical research. New features include data on nucleic acids condensate components, infectious condensates, condensate modulating drugs, and disease-linked condensates.
Understanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database
Keywords protein superfamily CATH database HUP domain ATP-pyrophosphatase substrate specificities structural motifs local structural comparison GMP synthase NAD synthase Introduction ATP-pyrophosphatase (ATP-PPase), together with high-motif proteins and universal stress protein, constitute the HUP domain superfamily.
Cardamonin protect against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1
Cardamonin protect against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1 Diabetic cardiomyopathy (DCM) contributes to a large proportion of heart failure incidents in the diabetic population, but effective therapeutic approaches are rare. Cardamonin (CAD), a flavonoid found in Alpinia, possesses anti-inflammatory and anti-oxidative activities.
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