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Articles by Jiaming Qiu
Optimizing Sequential Decision Rules for Prostate Cancer Biopsy Management: A Multi-Objective Statistical Framework.
Binary medical decision-making increasingly demands sequential diagnostic strategies that optimize accuracy while minimizing patient burden and healthcare costs. In prostate cancer diagnosis, many patients undergo unnecessary biopsies despite existing biomarkers and imaging tests that already inform risk stratification. Sequential testing, where tests are selectively administered based on prior results, offers a promising approach to balance diagnostic power with procedural efficiency.
Swarm intelligence-guided ROI selection for deep learning assessment of HER2 in colorectal cancer
Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) status in colorectal cancer (CRC) is pivotal for precision therapy, yet the gigapixel resolution of Whole Slide Images (WSIs) presents a significant computational bottleneck for traditional deep learning workflows that rely on exhaustive sliding-window tiling.
Optimizing Sequential Decision Rules for Prostate Cancer Biopsy Management: A Multi-Objective Statistical Framework
Abstract Binary medical decision-making increasingly demands sequential diagnostic strategies that optimize accuracy while minimizing patient burden and healthcare costs. In prostate cancer diagnosis, many patients undergo unnecessary biopsies despite existing biomarkers and imaging tests that already inform risk stratification. Sequential testing, where tests are selectively administered based on prior results, offers a promising approach to balance diagnostic power with procedural efficiency.
Alternative splicing–triggered mRNA decay informs splice-switching targets for neurodevelopmental disorders
Abstract Alternative splicing–triggered nonsense-mediated mRNA decay (AS-NMD) critically regulates gene expression, but the extent to which neuronal genes are regulated by AS-NMD remains understudied. Here, we identified over 3,000 developmentally regulated AS-NMD exons in mouse and human brains and validated them in cultured neurons. AS-NMD suppresses synaptic genes during brain development and differentially regulates more than 200 causal genes for neurodevelopmental disorders (NDDs).
Site‐Selective Tyrosine Reaction for Antibody‐Cell Conjugation and Targeted Immunotherapy
1 Introduction Targeted immunotherapies rely on the specific recognition of cancer cells for the precise killing of tumors.[1-5] For example, antibodies bring immune effector cells to the malignant cancer cells and eradicate the latter, an effect called antibody-dependent cellular cytotoxicity (ADCC).[6, 7] The antibody here serves as an engager to mediate cell-cell contacts in ADCC: The Fab domain of an Immunoglobulin G (IgG) antibody binds to the antigen expressed on the surface of cancer...
Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism
Thus far, researchers have mostly just monitored the body’s microbiome. Now they’re starting to modify it to treat disease.
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