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Jiayin Shou

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Articles

Excitatory paraventricular thalamus–posterior insular cortex circuit mediates pain–anxiety comorbidity in diabetic neuropathy

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By Min Wei, Jing Yang, Qiyuan Bai, Ye Jiang, Zhuoying Yu, Xinru Zhao, Yongzheng Han, Jie Cai, Xue-wei Yang, Zhengqian Li, Daqing Ma, Guo-Gang Xing, Min Li, Jiayin Shou, Siqing Cai, Jinwen Hou, Shixiong Shen
| Nature Verified
Abstract Painful diabetic neuropathy (PDN) is frequently accompanied by anxiety, yet the neural circuit mechanisms associated with nociceptive hypersensitivity to affective dysfunction remain unclear. Here we combined brain-wide c-Fos mapping, viral tracing, in vivo fiber photometry, whole-cell recordings, and projection-specific opto/chemogenetics in a mouse model of streptozotocin-induced PDN to define a thalamo–cortex circuit for pain–anxiety comorbidity.
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