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Zhuoying Yu

As seen in: Nature, Wiley Online Library, Dove Medical Press
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Articles

Excitatory paraventricular thalamus–posterior insular cortex circuit mediates pain–anxiety comorbidity in diabetic neuropathy

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By Min Wei, Jing Yang, Qiyuan Bai, Ye Jiang, Zhuoying Yu, Xinru Zhao, Yongzheng Han, Jie Cai, Xue-wei Yang, Zhengqian Li, Daqing Ma, Guo-Gang Xing, Min Li, Jiayin Shou, Siqing Cai, Jinwen Hou, Shixiong Shen
| Nature Verified
Abstract Painful diabetic neuropathy (PDN) is frequently accompanied by anxiety, yet the neural circuit mechanisms associated with nociceptive hypersensitivity to affective dysfunction remain unclear. Here we combined brain-wide c-Fos mapping, viral tracing, in vivo fiber photometry, whole-cell recordings, and projection-specific opto/chemogenetics in a mouse model of streptozotocin-induced PDN to define a thalamo–cortex circuit for pain–anxiety comorbidity.
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Development and Internal Validation of a Nomogram for Predicting Acute Moderate-to-Severe Postoperative Pain After Achilles Tendon Surgery: A Retrospective Cohort Study

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By Wenwen Zhai, Zhuoying Yu, Ning WANG
| Dove Medical Press
Back to Journals » Journal of Pain Research » Volume 19 Original Research Acute Pain and Perioperative Care Authors Zhai W , Yu Z , Wang N, Zhou J , Lv Y, Li M Received 4 May 2026 Accepted for publication 19 August 2026 Published 24 August 2026 Volume 2026:19 621775 DOI https://doi.org/10.2147/JPR.S621775 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Jinlei Li Wenwen Zhai, Zhuoying Yu, Ning Wang, Jiahong Zhou,...
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SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a‐PINK1‐Parkin signaling pathway to activate mitophagy

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By Jing Yang, Zhuoying Yu, Ye Jiang, Zixian Zhang
| Wiley Online Library Verified
1 INTRODUCTION The prevalence of type 2 diabetes mellitus (T2DM) is on the rise worldwide. Neuropathy is one of the most common long-term complications of diabetes and approximately 30%–50% of patients with diabetic neuropathy develop neuropathic pain (NP).1 The symptoms of painful diabetic neuropathy (PDN) include neuropathic pain and nerve fiber damage.
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