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Traditional Chinese Medicine Combined With Chemotherapy for Mammary Paget's Disease With Multifocal Heterogeneous Breast Cancer: A Case Report
1 Introduction Currently, breast cancer is the most common malignant tumor among women in China [1]. Among breast cancer, mammary Paget's disease, attributed to the “cell migration hypothesis,” is extremely rare, accounting for approximately 1%–3% of all breast cancer cases [2]. The incidence of multifocal breast cancer, attributed to the “two-hit” hypothesis, varies significantly across different studies, ranging from 6% to 77% [3-5].
Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis
Abstract Thermogenic brown and beige adipose tissues are important in maintaining metabolic health because of their distinct ability to catabolize stored fat and circulating glucose in futile cycles1,2. Macrophages, present in brown adipose tissue, have been reported to both positively and negatively regulate thermogenic adipocyte function through mechanisms that are incompletely understood3,4,5,6,7,8,9,10,11,12,13,14.
Field re-entrant superconductivity in Eu-doped infinite-layer nickelates
Abstract Intertwined superconducting and magnetic orders may give rise to exotic quantum phases1–7, including field-induced and re-entrant superconductivity8–10. However, such magnetism-enhanced superconductivity has remained elusive in superconductors with higher transition temperatures1–3. While infinite-layer nickelates represent a new class of unconventional superconductors11–20, the impact of rare-earth magnetism on superconducting properties remains largely unexplored.
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