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Jiehuang Wang

As seen in: PLOS, BioRxiv
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Articles

Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis

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By Xiaoqian Gong, Jiehuang Wang, Shanhuan Feng, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Gong X, Feng S, Wang J, Gao B, Xue W, Chu H, et al. (2025) Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis. PLoS Pathog 21(3): e1012987.
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Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response

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By Wenxiang Xue, Hongyan Chu, Jiehuang Wang, PLOS Pathogens
| PLOS
Fig 9. Role of PKCα/β activity in NUP62 phosphorylation, the cytoplasmic distribution of FG-Nups, suppression of the antiviral response, and virus replication. (A) Vero or DF-1 cells were infected with IBV at an MOI of 1 or mock-infected. Cells were harvested at 6, 12, and 18 h.p.i. and subjected to Western blot analysis using corresponding antibodies. The intensities of p-PKCα, p-PKCβ, and p-NUP62 bands were normalized to total PKCα/β or NUP62, respectively.
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Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

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By Ying Liao, Wenxiang Xue, Hongyan Chu, Jiehuang Wang
| BioRxiv
Abstract The hallmark of coronavirus infection lies in its ability to evade host immune defenses, a process intricately linked to the nuclear entry of transcription factors crucial for initiating the expression of antiviral genes. Central to this evasion strategy is the manipulation of the nucleocytoplasmic trafficking system, which serves as an effective target for the virus to modulate the expression of immune response-related genes.
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