In honor of Fast Company’s 10th Innovation Festival next week, we identified the industrious leaders whose groundbreaking efforts defined the past decade in business. We spoke to them about their extraordinary achievements in tech, medicine, entertainment, and more. And we explored how the impact of their work has withstood passing fads, various presidential administrations, a pandemic, and many, many quarterly reports. These are the 10 most innovative people of the last 10 years.