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Jin-Fu Xu

As seen in: Nature, Respiratory Research, EBioMedicine, European Respiratory Journal, Chest, TechTrends
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Articles

An immune-poised state of human bronchial epithelial cells mediates defense against RSV in adults

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By Caiqi Zhao, Yan Bai, Hongmei Mou, Paul H. Lerou, Daisy W Leung, Harish Narasimhan, Xiaoqin Wei, Jie Sun, Jin-Fu Xu, Rachel Fearns, Xingbin Ai
| Nature Verified
Abstract Respiratory syncytial virus (RSV) impairs STAT3 activation in infected ciliated cells in infants, but not adults, causing apoptosis to facilitate virus spread. How age regulates the STAT3 response to RSV in human bronchial epithelial cells (BEpiCs) is unknown.
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Pre-admission fine particulate matter exposure is associated with invasive pulmonary aspergillosis in patients with severe pneumonia, results from two multicenter cohort studies

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By Hua Zhou, Shupeng Zhu, John S. Ji, Jin-Fu Xu
| EBioMedicine Verified
Keywords Invasive pulmonary aspergillosis Particulate matter Severe pneumonia PM2.5 IPA Evidence before this study Invasive pulmonary aspergillosis (IPA) is one of the most lethal respiratory infections. Aspergillus spores are approximately 2.5 μm in diameter and are frequently detected in PM2.5 samples. Chronic obstructive pulmonary disease, a well-known risk factor for IPA, has also been causally linked to PM2.5 exposure.
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High level of initial Aspergillus fumigatus-specific IgE links increased risk of exacerbation in allergic bronchopulmonary aspergillosis patients - Respiratory Research

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By Hao Qian, Rui Fan, Jing Shi, Hai-Wen Lu, Jia-Wei Yang, Rui Jiang, Li-Sha Zhang, Yi-Fan Wu, Jin-Fu Xu, Jia-Yan Xu, Mei-Ling Jin
| Respiratory Research Verified
This study was a two-center retrospective study involving 149 ABPA patients at acute stage [9], including both newly diagnosed and exacerbation patients, conducted at Shanghai Pulmonary Hospital and Zhongshan Hospital between January 2018 and October 2023. The flowchart of patient inclusion and exclusion was shown in Fig. 1. The initial A. fumigatus-specific IgE referred to the levels of A. fumigatus-specific IgE measured in patients with acute-stage ABPA upon their visit to the two hospitals.
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