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Jing Han

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Articles

Immune–inflammatory–nutritional dysfunction in HIV-negative patients with asymptomatic neurosyphilis: a retrospective comparative study

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By Meidi Wang, Jun Wang, Jing Han, Yongxing Yan, Huiqin Cao
| Frontiers in Immunology
Abstract Objectives: The host’s immune function, inflammatory response, and nutritional status are closely related to the occurrence and development of neurosyphilis (NS). Asymptomatic neurosyphilis (ANS), as a completely curable type of NS, has received limited study on these fields.
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A targetable ALDH3A2-NRF2 axis mediates KEAP1-mutant tumour development via ferroptosis inhibition

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By Xiao Vincent Zhuang, Jing Han, Weiwei Cui, Yudan Zhang, Ziqi Wang, Dandan Song, Chao Zhou, Shaohui Huang, Kai Cui, Chenchen Lin, Min Xu, Xingru Zhao, Shuai Wang, Bin Huang, Hui Wang, Shuang Shi, Lutao Du, Qiankun Luo, Quncheng Zhang, Chengqian Yin, Bo Chu, Xiaoju Zhang, Zeheng Ma
| Nature Verified
Abstract The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of the cellular antioxidant response that defends against ferroptosis and facilitates tumour development. Here, by performing an aldehyde dehydrogenase (ALDH) family shRNA screen, our study identifies aldehyde dehydrogenase 3 family member A2 (ALDH3A2) as a potent NRF2 activator that inhibits ferroptosis.
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Shielded planning with acoustic link awareness enables USV and AUV cooperation

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By Jintao Wang, Jing Han, Sheng Zeng, Zhenxing Xu, Xusheng Hu, Wenge Yue
| Nature Verified
Abstract Cooperative unmanned surface vehicle (USV) and autonomous underwater vehicle (AUV) teams require planners that coordinate relay motion, underwater task execution, collision avoidance, and lossy acoustic communication. We present HACo-Safe, a domain-specific planning framework that integrates a planning-level acoustic-link surrogate, an interpretable warm-start controller, explicit action shielding, and a graph-attention multi-agent proximal policy optimization (MAPPO) distillation stage.
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