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Jing Wu

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Articles

FN3K deficiency drives tubular injury in diabetic kidney disease through impaired mitochondrial respiratory chain function

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By Dehan Cai, Jing Wu, Xionghui Yang, Mingjie He
| Frontiers
Abstract Aims: Despite growing evidence implicating FN3K in the pathogenesis of cancer and diabetes, its precise role in modulating renal tubular injury within the context of diabetic nephropathy has yet to be fully elucidated. Materials and methods: FN3K expression was examined in DKD model mice, human kidney biopsy samples, and high glucose-treated HK-2 cells via immunohistochemistry (IHC) and Western blotting.
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Comparative efficacy of therapeutic strategies for recurrent or refractory glioblastoma: a systematic review and network meta-analysis

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By Hao Zhang, Leilei Sun, Xianyong Yin, Yuming Li, Jing Wu, Zhihe Yun, Guangjian Dong
| Frontiers
Abstract Background: Recurrent or refractory glioblastoma has a poor prognosis, and no universally accepted standard treatment has been established. Randomized evidence is fragmented, making pairwise comparisons insufficient. This study aimed to compare available treatments using a frequentist network meta-analysis.
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Integrated multi-omics analysis of metabolomics and proteomics uncovers dysregulated amino acid metabolism in HCC metastasis

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By Jing Wu, Jin Wang, Zhen Yan Yu, Rui Yang
| Frontiers in Immunology
Abstract Background: Metastasis is the primary cause of treatment failure and adverse prognosis in hepatocellular carcinoma (HCC), and the molecular basis of HCC metastasis remains poorly defined. This work investigated the potential mechanisms underlying HCC metastasis through integrated multi-omics analysis of metabolomics and proteomics. Method: This retrospective study included 105 individuals with HCC, with comparative analysis between metastatic and non-metastatic cases.
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