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Jing-Ying Guo on Muck Rack

Jing-Ying Guo

As seen in: SAGE Publishing, JoVE- Journal of Visualized Experiments, Physiological Research
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Articles

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

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By Lu He, Jing-Ying Guo, Teng-Fei Qu, Yu-Ying Liu
| JoVE- Journal of Visualized Experiments
Fast-green dye was injected into the PSC of adult and neonatal mice to evaluate its immediate distribution in the inner ear. The dye was detected throughout the cochlea, vestibule, and semicircular canals immediately after surgery (Figure 4). To evaluate the safety and efficiency of canalostomy for inner ear gene delivery, AAV8-GFP was injected into the inner ear of adult and neonatal mice. All animals exhibited normal ABR thresholds and swimming test scores after AAV8-GFP injection18,30.
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