Jingan Chen on Muck Rack

Jingan Chen

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Articles

A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery

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By Muye Zhou, Yue Xu, Jingan Chen, Breanna Y. Seto, Fanglin Gong, Tyler Thomson, Juan Chen, Songtao Dong, David Chen Verified, Christabel Eileen, Shiqi Wu, Gang Zheng, Bowen Li, Margarita Savguira
| Nature Verified
Abstract Lipid nanoparticle (LNP) delivery of RNA therapeutics is constrained by poor tissue selectivity and off-target toxicity. Most high-throughput screening approaches have focused on single-target efficacy while overlooking off-target uptake.
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Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung

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By Fanglin Gong, Yue Quan Xu, Jingan Chen, Shun Zhang, Songtao Dong, Lauren Healy, Breanna Y. Seto, Tyler Thomson, Yinghua Tang, Ziyan Chen, Andrew Varley, David Chen, Craig Hodges, Amy Wong, Jim C. Hu, Basil P. Hubbard, John F. Engelhardt, Ziying Yan, Bowen Li, Muye Zhou, Krista Antonio
| Nature Verified
Abstract CRISPR-based gene editing holds promise for treating genetic diseases, yet its application to lung disorders has been hindered by the challenges of pulmonary delivery. Inspired by the modularity and biocompatibility of amino acid-derived chemistries, we report the combinatorial synthesis of 960 ionizable lipids incorporating chemically diverse backbones from both proteinogenic and non-proteinogenic α-amino acids.
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A modular mRNA platform for programmable induction of tumour-specific immunogenic cell death - Nature Nanotechnology

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By Songtao Dong, Nicholas C. Solek, Lauren Healy, Jingan Chen, Alex Golubovic, Benjamin H. Lok, Housheng Hansen He
| Nature Verified
Abstract Messenger RNA (mRNA) therapeutics hold great promise for oncology but their efficacy is limited by systemic off-target effects and immunosuppressive tumour microenvironments. Here we present TITUR, a tumour-customizable mRNA nanomedicine platform that integrates tumour-customizable ionizable lipids (TIs) and tumour-specific untranslated regions (TURs) to enhance tumour-selective mRNA delivery and expression.
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