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Jirina Bartkova

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Articles

Nucleoporin TPR integrates MAPK signaling with mitogen-induced transcriptional programs

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By Jin Liu, Yifan Zheng, Yi Xiong, Zihao Lin, Haikun Lin, Jian Liu, Marco Foiani, Jiri Bartek, Runhua Ma, Miguel Andújar-Sánchez, Jirina Bartkova, Martin Kosar
| Nature Verified
Abstract The nuclear pore complex (NPC) component TPR has emerged as a multifunctional scaffold implicated in mitosis, chromatin organization, mRNA export, and genome stability. However, TPR’s role in mitogenic signal transduction remains largely unexplored. Here, we investigate whether nucleoporin TPR functions as a MAPK-regulated nuclear component that modulates mitogenic signals initiated at the plasma membrane—including EGFR activation—and their transcriptional output.
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