Jiuxiu Lin on Muck Rack

Jiuxiu Lin

As seen in: Cell Reports
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Articles

Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer

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By Qiang Zhang, Kaisa Cui, Yue KONG, Jing Yu, Xiaoya Yang, Yanchun Xie, Jiuxiu Lin, Chen Liu, Zongjin Zhang, Yugeng Liu, Bingxin Liu, Zhen He, Ping Lan, Zhanhao Luo, Dayi Liang, Wanyi Zeng
| Cell Reports Verified
Keywords c-Myc-driven cancer DHODH Myc EN4 pyrimidine metabolism metabolic and non-metabolic roles Research topic(s) CP: Cancer CP: Metabolism Introduction c-Myc (Myc) is a well-known oncogene that is frequently found to be amplified and overexpressed in various human cancers.1,2 Its dysregulation has been implicated in altering crucial cellular processes such as metabolism, translation, and other key functions that contribute to tumor initiation and progression.3,4,5,6,7 Myc-driven cancers,...
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PTBP1 is upregulated by Zika virus infection via HIF-1alpha signal and hijacks NS1 protein to induce NS1 degradation to restrain viral replication

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By Zhiwei Lei, Shuang Liu, Menglan Rao, Jiuxiu Lin
| biorxiv.org
Abstract Zika virus (ZIKV), belonging to the Flaviviridae family, has been a severe threat to human health since the worldwide outbreak. ZIKV is capable of inducing fetal microcephaly, Guillain-Barre syndrome, and other serious neurological complications. Polypyrimidine tract-binding protein 1 (PTBP1) is a key member of the heterogeneous nuclear ribonucleoproteins (hnRNPs) family, functioning in selective mRNA splicing and gene expression regulation.
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