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Jo Anne A. Stratton on Muck Rack

Jo Anne A. Stratton

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Articles

PD-1 regulates CD4 + T cell-mediated CD8 + T cell responses in the brain to balance viral control and neuroinflammation

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By Arrienne B. Butic, Elia Afanasiev, Samantha Spencer, Mofida Abdelmageed, Anirban Paul, Todd D Schell, Matthew D. Lauver, Ge Jin, Samantha M. Borys, Rachel Kang, ChaeMin Kim, Elizabeth Proctor, Laurent Brossay, Vonn Walter, Aron Lukacher, Kalynn M. Alexander, Katelyn N. Ayers, Jo Anne A. Stratton
| Nature Verified
Abstract Programmed cell death protein 1 (PD-1) is expressed by T cells during progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease caused by the human-only JC polyomavirus (JCPyV). PD-1 checkpoint immunotherapy has benefited some PML patients, but reasons for its variable outcomes are unclear.
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