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Mofida Abdelmageed on Muck Rack

Mofida Abdelmageed

As seen in: Nature, BioRxiv, eLife
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Articles

PD-1 regulates CD4 + T cell-mediated CD8 + T cell responses in the brain to balance viral control and neuroinflammation

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By Arrienne B. Butic, Elia Afanasiev, Samantha Spencer, Mofida Abdelmageed, Anirban Paul, Todd D Schell, Matthew D. Lauver, Ge Jin, Samantha M. Borys, Rachel Kang, ChaeMin Kim, Elizabeth Proctor, Laurent Brossay, Vonn Walter, Aron Lukacher, Kalynn M. Alexander, Katelyn N. Ayers, Jo Anne A. Stratton
| Nature Verified
Abstract Programmed cell death protein 1 (PD-1) is expressed by T cells during progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease caused by the human-only JC polyomavirus (JCPyV). PD-1 checkpoint immunotherapy has benefited some PML patients, but reasons for its variable outcomes are unclear.
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An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

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By Mofida Abdelmageed, Victoria Vernail, Premkumar Palanisamy
| eLife
eLife Assessment This manuscript details important findings that DNA polymerase kappa shows age-related changes in subcellular localization within different cell types in the brains of mice, from the nucleus in young cells to the cytoplasm in old cells. The authors' findings suggest that age-related alterations in POLK localization could drive mechanistic and functional changes in the aging brain.
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An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

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By Mofida Abdelmageed, Yuval Silberman, Premkumar Palamisamy, Victoria Vernail
| BioRxiv
Abstract Genomic stability is critical for cellular function, however, in the central nervous system highly metabolically active differentiated neurons are challenged to maintain their genome over the organismal lifespan without replication. DNA damage in neurons increases with chronological age and accelerates in neurodegenerative disorders, resulting in cellular and systemic dysregulation. Distinct DNA damage response strategies have evolved with a host of polymerases.
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