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Jo-Fan Chien on Muck Rack

Jo-Fan Chien

As seen in: Nature, BioRxiv, Cell Press
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Articles

Author Correction: Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation - Nature Communications

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By Junhao Li, manoj JAISWAL, Jo-Fan Chien, Erica Engelberg-Cook, Dennis W. Dickson, Veronique V. Belzil, Eran A. Mukamel
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-41033-y, published online 15 September 2023 The original version of this Article contained blurry figures in the Supplementary information file. In the original Supplementary information file, Supplementary Figs. 8, 10 and 11 were inadvertently of lower resolution, making them blurry and illegible.
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Cell-type-specific effects of age and sex on human cortical neurons

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By Byne W.M, Jo-Fan Chien
| Cell Press Verified
Highlights • Single-cell multiomes (DNA methylation+RNA) from aged and young adult human cortex • Upper layer excitatory neurons are more impacted by aging than inhibitory cells • The proportion of SST- and VIP-expressing neurons is reduced in aged donors • Aging reduces synaptic gene expression and increases subtelomeric gene expression Summary Altered transcriptional and epigenetic regulation of brain cell types may contribute to cognitive changes with advanced age.
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Cell type-specific effects of age and sex on human cortical neurons

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By Jo-Fan Chien, Hanqing Liu, Chongyuan Luo, Bang-An Wang
| BioRxiv
Abstract Excitatory and inhibitory neurons establish specialized identities early in life through cell type-specific patterns of epigenetic regulation and gene expression. Although cell types are largely stable throughout the lifespan, altered transcriptional and epigenetic regulation may contribute to cognitive changes with advanced age.
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