Joannie St-Germain

Keywords chromatin regulation neurodevelopment cellular differentiation methyl-histone regulation alternative splicing genetics of autism spectrum disorder Research topic(s) CP: Molecular biology CP: Neuroscience Introduction A long-standing question in biology is how cell-type-specific transcription programs emerge and progress during metazoan development. DNA-binding transcription factors (TFs) play crucial roles in this process.

Abstract : Most pseudogenes are generated when an RNA transcript is reverse-transcribed and integrated into the genome at a new location. Pseudogenes are often considered as an imperfect and silent copy of a functional gene because of the accumulation of numerous mutations in their sequence. Here we report the presence of Pfh8-ps, a Phf8 retrotransposed pseudogene in the mouse genome, which has no disruptions in its coding sequence.