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Articles by John Castle
Let do nebezpečí - Arthur Hailey
O knize Let do nebezpečí Námětem novely je dramatický let a přistávání dopravního letadla, řízeného v krajní nouzi nekvalifikovaným pilotem, někdejším válečným stíhačem. Co říkají o knize uživatelé? Kniha "Let do nebezpečí" od Arthura Haileyho zanechává silný dojem na čtenáře i posluchače. Mnozí uživatelé chválí napínavý děj a výbornou dramatizaci, která přináší nezapomenutelný zážitek. I po letech si příběh udržuje svou atraktivitu a dokáže vtáhnout do atmosféry letu.
Let do nebezpečí
O knize Let do nebezpečí Příběh posádky letadla, která je vyřazena z činnosti po otravě jídlem, čímž je ohrožen život pasažérů na palubě. Kniha patří k tomu nejlepšímu v žánru katastrofické literatury. Co říkají o knize uživatelé? Kniha "Let do nebezpečí" od Arthura Haileyho zanechává silný dojem na čtenáře i posluchače. Mnozí uživatelé chválí napínavý děj a výbornou dramatizaci, která přináší nezapomenutelný zážitek. I po letech si příběh udržuje svou atraktivitu a dokáže vtáhnout do atmosféry letu.
Commetary | John Castle: What we’re missing with education transformation in Vermont
"The old system is not only failing our teachers, it’s failing our kids. Just this past fall, the Boston Globe reported that over the last decade 'no state fell as far in early reading as Vermont.' Ten years ago, we were top five in the nation in 4th grade reading. In 2024, we ranked 37, and the same pattern repeats across grade and subject." — Gov.
Castle: Missing in education transformation
'The old system is not only failing our teachers, it’s failing our kids. Just this past fall, the Boston Globe reported that over the last decade 'no state fell as far in early reading as Vermont.' Ten years ago, we were top five in the nation in 4th grade reading. In 2024, we ranked 37, and the same pattern repeats across grade and subject." — Gov. Phil Scott’s State of the State address, January. Although his intent was undoubtedly a call to action to push forward with Act 73, Gov.
FCC issues submarine cable rules, seeks comment on additional proposal | JD Supra
[co-author: Fernando Margarit] In August, the Federal Communications Commission (“FCC”) adopted a Report and Order and Further Notice of Proposed Rulemaking (FCC 25-49) to modernize its submarine cable licensing rules.
U.S. Supreme Court upholds FCC’s Universal Service Fund framework | JD Supra
The Supreme Court’s recent ruling in Federal Communications Commission (FCC) v. Consumers’ Research removed the uncertainty that hung over the FCC’s Universal Service Fund (USF) programs since July 2024, when the U.S. Court of Appeals for the Fifth Circuit declared that the USF contribution mechanism was unconstitutional.
U.S. Supreme Court upholds FCC’s Universal Service Fund framework
Background Originally, the Communications Act of 1934 tasked the FCC with making communications services available to all the people of the United States at reasonable prices, which the FCC achieved through rate regulation.
Holland Town Meeting
Voters give school building to the town by John Castle HOLLAND — Before getting underway, Senator Russ Ingalls and Representative Larry Labor were provided an opportunity to share updates on various legislative considerations at the State House. Moderator Mitch Wonson officially opened the meeting with a welcome to the approximately 40 people assembled at 10:19 a.m. Then Mr. Wonson was formally reelected town moderator for the ensuing year.
Holland Town Meeting
Voters give school building to the town by John Castle HOLLAND — Before getting underway, Senator Russ Ingalls and Representative Larry Labor were provided an opportunity to share updates on various legislative considerations at the State House. Moderator Mitch Wonson officially opened the meeting with a welcome to the approximately 40 people assembled at 10:19 a.m. Then Mr. Wonson was formally reelected town moderator for the ensuing year.
Be brave, little state, defend public education
Gov. Phil Scott has provided his shock and aw-shucks proposal for rescuing taxpayers and claiming to improve education along the way. Finding renewed hubris with the “red wave” of new Republicans in the Statehouse and Democrats running scared, Gov. Scott is seizing the opportunity with a misguided overhaul of our public education system. It is time for Vermonters to defend our equitable, successful and essential public schools and local governance.
Be brave little state, defend public education
Governor Phil Scott has provided his shock and aw-shucks proposal for rescuing taxpayers and claiming to improve education along the way. Finding renewed hubris with the “red wave” of new Republicans in the State House and Democrats running scared, Governor Scott is seizing the opportunity with a misguided overhaul of our public education system. It is time for Vermonters to defend our equitable, successful and essential public schools and local governance.
Column: Be brave, little state, and defend public education
E-Edition Advertise Newsletters Subscribe Home News Opinion Sports Photos Arts & Life Obituaries Classifieds Calendar Puzzles By JOHN A. CASTLE For the Valley News Published: 02-18-2025 12:27 PM Gov. Phil Scott has provided his shock and aw-shucks proposal for rescuing taxpayers and claiming to improve education along the way. Finding renewed hubris with the “red wave” of new Republicans in the Statehouse and Democrats running scared, Gov.
Commentary | John Castle: Be brave little state, defend public education
Governor Phil Scott has provided his shock and aw-shucks proposal for rescuing taxpayers and claiming to improve education along the way. Finding renewed hubris with the “red wave” of new Republicans in the State House and Democrats running scared, Governor Scott is seizing the opportunity with a misguided overhaul of our public education system. It is time for Vermonters to defend our equitable, successful and essential public schools and local governance.
Castle: Be brave little state, defend public education
Gov. Phil Scott has provided his shock and aw-shucks proposal for rescuing taxpayers and claiming to improve education along the way. Finding renewed hubris with the “red wave” of new Republicans in the State House and Democrats running scared, Governor Scott is seizing the opportunity with a misguided overhaul of our public education system. It is time for Vermonters to defend our equitable, successful and essential public schools and local governance.
Op-ed: Be Brave Little State, Defend Public Education
The Chester Telegraph | Feb 12, 2025 | Comments 0 By John Castle Governor Phil Scott has provided his shock and aw-shucks proposal for rescuing taxpayers and claiming to improve education along the way. Finding renewed hubris with the “red wave” of new Republicans in the State House and Democrats running scared, Governor Scott is seizing the opportunity with a misguided overhaul of our public education system.
Winnik panelists discuss the impact of Loper Bright on FCC rulemaking | JD Supra
Understanding the implications of Loper Bright requires understanding Chevron. The Chevron doctrine involved a two-step analysis. First, courts asked whether Congress had spoken clearly on an issue in a given statute. When Congress had not spoken clearly, courts then determined whether the agency’s interpretation of the statute was reasonable. Loper Bright rejected this framework, shifting authority from agencies to courts.
Winnik panelists discuss the impact of Loper Bright on FCC rulemaking
News Agency Determinations Carry Less Weight Understanding the implications of Loper Bright requires understanding Chevron. The Chevron doctrine involved a two-step analysis. First, courts asked whether Congress had spoken clearly on an issue in a given statute. When Congress had not spoken clearly, courts then determined whether the agency’s interpretation of the statute was reasonable . Loper Bright rejected this framework, shifting authority from agencies to courts.
Shelf Drilling Board of Directors Approves Share Issue and Grant of RSUs
Market Closed - 10:45:00 2024-11-13 am EST 5-day change 1st Jan Change 13.95 NOK -0.71% -6.06% -51.90% Nov. 12 DNB lowers target price for Shelf Drilling to 35 Norwegian kroner (40), reiterates buy - BN FW Nov. 04 Shelf Drilling, Ltd. Announces Two Contract Extensions in Thailand CI November 13, 2024 at 01:08 pm EST PRESS RELEASE SHELF DRILLING BOARD OF DIRECTORS APPROVES SHARE ISSUE AND GRANT OF RSUS Dubai, November 13, 2024: Reference is made to the announcement by Shelf Drilling, Ltd.
Adapting to Change: Winnik panelists discuss regulatory changes in a shifting geopolitical landscape | JD Supra
Panelist Greta Lundeberg, Vice President and Head of Government and Policy Advocacy for the Americas at Ericsson, discussed how multinational tech and telecom companies must navigate diverse regulatory environments worldwide and adapt to varying standards and regulations across different markets. These different standards can sometimes conflict with each other, impede innovation and scalability, and increase costs for regulated businesses and consumers alike.
Winnik Forum participants predict sustained scrutiny of foreign ownership in the U.S. tech and telecom sectors | JD Supra
In a fireside chat, Commissioner Geoffrey Starks, of the Federal Communications Commission (FCC), discussed efforts to address national security threats to U.S. telecommunications networks, including hjs strong advocacy in favor of the FCC’s Rip and Replace Program, which requires telecom carriers to remove from their networks equipment manufactured by entities on the FCC’s Covered List (designating equipment found to pose a threat to national security by federal national security agencies),...
FCC to consider new TCPA requirements for using AI-generated content in robocalls and robotexts | JD Supra
The draft NPRM proposes to define “AI-generated call” as “a call that uses any technology or tool to artificially generate a voice or text using computational technology or other machine learning, including predictive algorithms, and large language models, to process natural language and produce voice or text content to communicate with a called party over an outbound telephone call.” The element “to communicate with a called party over an outbound telephone call” is intended to tailor the...
FCC to consider new TCPA requirements for using AI-generated content in robocalls and robotexts
The Federal Communications Commission (FCC) released a draft Notice of Proposed Rulemaking (NPRM) that would expand its Telephone Consumer Protection Act (TCPA) rules for callers when they use AI technologies to place calls or send texts, with the goal of protecting consumers from abusive or fraudulent behavior.
State attorneys general ask FCC to clarify TCPA requirements for AI calls | JD Supra
The Federal Communications Commissions (FCC) published a Notice of Inquiry (NOI) last fall about the implications of emerging artificial intelligence technologies on the Telephone Consumer Protection Act (TCPA) and related FCC rules. Attorneys general from 26 states (State AGs) submitted a joint comment asking the FCC to clarify that the TCPA’s prohibition on artificial voice calls or messages applies to AI-generated human voices.
State attorneys general ask FCC to clarify TCPA requirements for AI calls
The Federal Communications Commissions (FCC) published a Notice of Inquiry (NOI) last fall about the implications of emerging artificial intelligence technologies on the Telephone Consumer Protection Act (TCPA) and related FCC rules. Attorneys general from 26 states (State AGs) submitted a joint comment asking the FCC to clarify that the TCPA’s prohibition on artificial voice calls or messages applies to AI-generated human voices.
An evaluation of clinical fellow programmes in an acute teaching hospital trust
Clinical fellows support the hospital workforce while gaining experience in different specialities, research, leadership and teaching. The authors aimed to assess the impact of clinical fellow programmes in an acute teaching hospital trust. An anonymous electronic service evaluation was sent to clinical fellows to investigate their views on whether the programme had improved patient safety, doctors' clinical performance, training and wellbeing.
The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer
Proliferation Thrombin at 10 U/mL increased proliferation of SW620 cells from 48 h onwards compared to vehicle control (Figure 1A). Thrombin at lower concentrations did not affect proliferation and did not affect proliferation in the DLD-1 cell line (Figure 1B). FXa had no effect on proliferation in the SW620 cell line (Figure 1C), but increased proliferation of DLD-1 cells at a concentration of 1.0 U/mL from 48 h onwards (Figure 1D).
FCC seeks comment on additional TCPA consent rules | JD Supra
At its June Open Commission Meeting, the Federal Communications Commission (FCC) adopted a Notice of Proposed Rulemaking (NPRM) that proposes to amend its rules implementing the Telephone Consumer Protection Act (TCPA) and codify the agency’s past guidance on “prior express consent.” The comment period offers businesses a valuable opportunity to engage with the Commission on the operational challenges and business considerations implicated by these rules.
FCC seeks comment on additional TCPA consent rules
At its June Open Commission Meeting, the Federal Communications Commission (FCC) adopted a Notice of Proposed Rulemaking (NPRM) that proposes to amend its rules implementing the Telephone Consumer Protection Act (TCPA) and codify the agency’s past guidance on “prior express consent.” The comment period offers businesses a valuable opportunity to engage with the Commission on the operational challenges and business considerations implicated by these rules.
Rivaroxaban targets procoagulant fibroblasts in the tumour microenvironment to reduce breast cancer cell migration and stem cell activity
Emma Blower John Castle Angelica Santiago-Gomez Robert Clarke Cliona Kirwan Introduction: Breast cancer-associated fibroblasts express tissue factor (TF), creating a procoagulant tumour microenvironment. TF activates PAR2 to promote cancer cell proliferation, metastasis and stem cell activity. Rivaroxaban, a licensed oral anticoagulant which inhibits TF-FVIIa-FXa, could be repurposed as an anticancer therapy.
Coronavirus: The Hill and the Headlines, May 2021 # 11 | JD Supra
Your guide to the latest Hill developments, news narratives, and media headlines from Hogan Lovells Government Relations and Public Affairs practice. In Washington: President Biden on Wednesday asked U.S. intelligence to “redouble their efforts” to determine the origins of the coronavirus and submit a report within 90 days on whether the virus emerged from an accidental lab leak.
02. A hypercoagulant tumour microenvironment promotes breast cancer progression, with effects inhibited by anticoagulants
Emma Blower Emma Blower Affiliations Manchester Cancer Research Centre, The Oglesby Cancer Research Building, University of Manchester, Manchester, United Kingdom Search for articles by this author John Castle John Castle Affiliations Manchester Cancer Research Centre, The Oglesby Cancer Research Building, University of Manchester, Manchester, United Kingdom Search for articles by this author Angelica Santiago-Gomez Angelica Santiago-Gomez Affiliations Manchester Cancer Research Centre, The...
Unanimous Supreme Court rejects expansive interpretation of TCPA autodialer definition
Hogan Lovells | Tech, Data, Telecoms & Media - USA John Castle, Arpan Sura, Ambia Harper Uncertainty over the definition of an 'automatic telephone dialling system' under the Telephone Consumer Protection Act has fuelled a steady flow of litigation for over a decade. In 2020 four federal courts of appeals addressed the issue, with no consensus on the proper scope of the statutory definition.
Unanimous Supreme Court rejects expansive interpretation of TCPA autodialer definition | JD Supra
Uncertainty over the definition of an “automatic telephone dialing system” (ATDS or autodialer) under the Telephone Consumer Protection Act (TCPA) has fueled a steady flow of litigation for over a decade. Last year, four federal courts of appeals addressed the issue, with no consensus on the proper scope of the statutory definition. In Facebook, Inc. v.
U.S. Government urges Supreme Court to adopt reasonable interpretation of ATDS in TCPA case | JD Supra
[co author: Ambia Harper] The Supreme Court recently granted certiorari in Facebook, Inc. v. Duguid to resolve a deepening circuit split on the question of what qualifies as an automatic telephone dialing system (ATDS or autodialer) under the Telephone Consumer Protection Act (TCPA). This week, the Department of Justice (DOJ) filed a brief in support of Facebook, arguing that only technology with the capacity to use a random or sequential number generator satisfies the statutory definition of ATDS.
FCC identifies promising opportunities to expand spectrum resources for unmanned aircraft systems | JD Supra
[co-author: Ambia Harper] As unmanned aircraft systems (UAS) are employed in an ever-expanding number of industries and use cases, demand for access to radiofrequency spectrum to support UAS operations has increased.
05. TARGETING THE PROCOAGULANT TUMOUR MICROENVIRONMENT IN BREAST CANCER
Emma Blower Emma Blower Affiliations Cancer Research UK Manchester Institute, The Oglesby Cancer Research Centre, The University of Manchester, United Kingdom Search for articles by this author John Castle John Castle Affiliations Cancer Research UK Manchester Institute, The Oglesby Cancer Research Centre, The University of Manchester, United Kingdom Search for articles by this author Robert Clarke Robert Clarke Affiliations Cancer Research UK Manchester Institute, The Oglesby Cancer Research...
Seventh Circuit Joins Third and Eleventh Circuits in “Autodialer” Circuit Split
Slowly but surely, the U.S. Courts of Appeal increasingly agree on how to interpret the definition of “automatic telephone dialing system” (“ATDS” or “autodialer”) in the Telephone Consumer Protection Act (“TCPA”). On February 19, 2020, a unanimous Seventh Circuit panel refused to revise a putative class action in Gadelhak v. AT&T Services, Inc. after concluding that the dialing system used by AT&T did not qualify as an autodialer. Like the Eleventh Circuit in Glasser v.
Seventh Circuit Joins Third and Eleventh Circuits in “Autodialer” Circuit Split | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Seventh Circuit Joins Third and Eleventh Circuits in “Autodialer” Circuit Split
Slowly but surely, the U.S. Courts of Appeal increasingly agree on how to interpret the definition of “automatic telephone dialing system” (“ATDS” or “autodialer”) in the Telephone Consumer Protection Act (“TCPA”). On February 19, 2020, a unanimous Seventh Circuit panel refused to revise a putative class action in Gadelhak v. AT&T Services, Inc. after concluding that the dialing system used by AT&T did not qualify as an autodialer. Like the Eleventh Circuit in Glasser v.
Congress Passes Bipartisan Robocall Legislation | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Congress Passes Bipartisan Robocall Legislation
On December 19, 2019, the U.S. Senate unanimously passed the Pallone-Thune Telephone Robocall Abuse Criminal Enforcement and Deterrence (TRACED) Act (S. 151), which the House of Representatives passed in a 417-3 vote earlier this month. With the Senate’s passage of the reconciled bill, the bipartisan legislation now heads to President Trump’s desk for his review.
California Enacts Another CCPA – Robocall Legislation | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
2019 Winnik International TMT Forum: Media and Technology Convergence Panel | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Lighthouse Lane | MyIndie Productions
Horror, Mystery, Thriller / 75 min / 2010 No one escapes the madness on Lighthouse Lane. Dawn Snyder, a 25 year old college student, drops out of Yale after becoming mentally ill. Moving back home with her overbearing mother, Dawn spirals downward in a haze of psychotic delusions and nightmarish hallucinations. She soon discovers there is no escape from the madness on Lighthouse Lane.
Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways
David M Levine1, David R Haynor2, John C Castle1, Sergey B Stepaniants1, Matteo Pellegrini3, Mao Mao1 and Jason M Johnson1Email author Genome Biology20067:R93 https://doi.org/10.1186/gb-2006-7-10-r93 © Levine et al.; licensee BioMed Central Ltd.
“Gateway” Argument Persists In Failing To Materialize
The Washington Examiner has offered an illuminating opinion piece which skillfully debunks the “vaping is a gateway to smoking” myth, making it another myth to add to the pile. (See: Five Vaping Myths, Debunked.) The raw CDC data, released last week in its Morbidity and Mortality Report, is devastating to this long repeated gateway myth: When the CDC began monitoring the smoking habits of teenagers in 2011, 15.8 percent reported as having smoked. By 2016, this number had fallen to 8 percent.
Coagulation as a pharmacodynamic biomarker in breast cancer: Changes in tumour expression of extrinsic clotting factors in response to breast cancer treatment
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Introduction: Short term treatment of ER-positive early breast cancer (EBC) with aromatase inhibitors (AI) inhibits proliferation. To access this article, please choose from the options below Purchase access to this article Claim Access If you are a current subscriber with Society Membership or an Account Number, claim your access now.
Update for Thrombin Inhibition Preoperatively (TIP) in early breast cancer, the first clinical trial of DOACs as an anti-cancer agent
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Introduction: The extrinsic clotting pathway promotes cancer progression and is upregulated in aggressive breast cancer subtypes (ER-ve, high proliferation). Cancer stem-like cells (CSCs) are a subpopulation of cancer cells that are resistant to treatment and play a role in recurrence.
Evidence for the role of procoagulant stromal fibroblasts in the progression of Ductal Carcinoma in Situ
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Introduction: Stromal fibroblasts play an active role in the transition from DCIS to invasive cancer by developing a malignant phenotype and facilitating cancer progression. We previously demonstrated that fibroblast expression of procoagulant markers are increased in DCIS compared to normal breast.
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