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Articles by John Common
Malassezia and the Asian menopausal skin
Abstract Menopause is accompanied by skin changes, including complaints of itch, redness, and dry skin, linked to epidermal thinning and reduced sebaceous gland activity. These changes can cause microbiome dysbiosis, leading to dermatoses. Malassezia, a ubiquitous, lipid-dependent, and dominant skin fungus, is associated with multiple skin and systemic diseases. However, the mechanism for its pathogenicity in the context of host physiological changes, such as menopause, remains unexplored.
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
Keywords UV skin ribotoxic stress response ZAK-alpha pyroptosis apoptosis inflammation p38 JNK Introduction Skin separates the organism from its surroundings and provides a barrier against the external environment, trauma, and infection. In this capacity, the skin is also the most exposed part of our body and is constantly challenged with radiation, chemical irritants, and thermal fluctuations.
Performing Skin Microbiome Research: A Method to the Madness
Heidi H. Kong, Bj?rn Andersson, Thomas Clavel, John E. Common, , , Julia Segre, Claudia Traidl-Hoffman Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis. The need for common language, effective study design, and validated methods is critical for high-quality standardized research.
RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis
Introduction Recessive X-linked ichthyosis (RXLI) is a genetic disorder occurring in approximately 1:1500 males (Craig et al., 2010). The disease presents in the first year of life with scaling and erythema developing with time into brown polygonal scales most marked on the shins, neck and abdomen but generally sparing the palmoplantar skin and flexures.
This paper is only available as a PDF. To read, Please Download here. Abstract Background Atopic dermatitis (AD) is a common chronic skin condition in children (15-20%) that can significantly impair their quality of life. Due to its relapsing nature and enrichment of Staphylococcus aureus during flares, clinical management can include eradicating S. aureus from the skin of children, however this does not extend to their healthy caregivers who are potential reservoirs.
Keratinocytes maintain compartmentalization between dermal papilla and fibroblasts in 3D heterotypic tri‐cultures
1 INTRODUCTION The hair follicle is often considered a mini organ residing in the dermal layer of the skin.
Cover Image, Volume 52, Issue 5
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Keratinocytes maintain compartmentalization between dermal papilla and fibroblasts in 3D heterotypic tri‐cultures - Tan - - Cell Proliferation - Wiley Online Library
Abstract Objectives Reproducing human hair follicles in vitro is often limited by various reasons such as the lack of a systematic approach to culture distinct hair follicle cell types to reproduce their spatial relationship. Here, we reproduce hair follicle‐like constructs resembling the spatial orientation of different cells in vivo, to study the role of keratinocytes in maintaining cellular compartmentalization among hair follicle‐related cells.
Insights into atopic dermatitis gained from genetically defined mouse models
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig 1 Pathogenesis of AD (AD trinity) and its possible interaction with the skin microbiome. Signature features of AD are an impaired skin barrier, aberrant TH2-type cytokine production, and intensive pruritus. These mutually interacting characteristics contributing to the development of AD are conceptualized as the trinity of AD pathogenesis.
3 Reasons to Join Us for the Marketing Nation Roadshow
The Marketing Nation Roadshows are back! In just a few short weeks, we’re hitting the road, and we’re bringing the Marketing Nation with us! If you haven’t registered yet, I can assure you this year’s roadshow is not to be missed! So, if you’re in Boston, Chicago, or London—or if you’re traveling to any of these cities—you’ll need to add the Marketing Nation Roadshow to your calendar.
Should You Incorporate Chat Into Your Marketing Plan?
Marketers are constantly on the lookout for new and exciting ways to engage their existing users and acquire new ones. And with new marketing solutions being offered to brands every other day, choosing the right one that will best suit their needs and help them promote their business to a vast number of users is crucial.
How Facebook Watch Will Change the Game for Marketers
Facebook’s recently announced (Wednesday, August 9) that the company is expanding their already robust platform by adding an episodic streaming video platform—Facebook Watch. Unlike the company’s venture into related video content, which launched in 2015, Watch seems to initially compete directly with YouTube, with the potential to creep into Netflix’s original series market share.
Healthcare Marketers: It’s Time to Transform
In healthcare, extraordinary technology and innovative strategies exist side-by-side with last century’s tools, systems, and out-of-date status quo. This old world/new world dichotomy makes healthcare operations difficult and confusing. And it’s the same with healthcare marketing. The promise and payoff of modern marketing often seems out of reach to healthcare marketers. It’s easy to buy software, but it’s difficult to transform. How do you navigate the regulatory waters?
The 6 Truths About UX Design
If you’ve ever worked in retail, you’ve probably heard some form of the phrase “The customer’s always right.” Despite any problems this philosophy may have caused you as a cashier, it’s popular because it makes sense. Businesses, of course, revolve around the customers. Without them, the company wouldn’t exist, so it’s important to give them what they need to have a positive experience.
SiriusDecisions: The New Demand Unit Waterfall
We know that audience-centric go-to-market strategies outperform product-centric go-to-market strategies. But how do you become more audience-centric? A great place to start (and stay) is to become an expert in their needs of your target audience, and map them to your value proposition, solutions and products. And in B2B, your target audience’s needs exist at multiple levels.
Not Groundhog Day: Takeaways from the MarTech Conference in San Francisco
But my “Groundhog Day Loop” was immediately interrupted when I stepped inside. First, the Hilton wisely installed a new, well-stocked bar right in the center of the lobby. “Way to optimize, fellas. I’m already seeing improvement.” Most conferences I attend offer the following: Some conferences also throw in extras: While MarTech skipped the extra trappings (good call, in my opinion), they offered everything on the first list in spades.
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