John Cryan on Muck Rack

John Cryan

Cork
As seen in: Color Research & Application, Nature, The Independent (UK), Wiley Online Library, rakuten.co.jp, Cambridge University Press & Assessment, PLOS, RTVE, ScienceDirect, The Journal of Nutrition and
Vice President for Research & Innovation @ucc @UCCResearch @UCCInnovation| PI @pharmabiotic| Prof @AnatNeuroUCC| MRIA @RIAdawson| Bluesky @jfcryan.bsky.social
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Articles

Towards ecological psychiatry: The herbicide glyphosate disrupts behavior through microbiota-gut-brain axis

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By Benjamin Valderrama, Patrick Fitzgerald, Gerard Clarke, Eoin Gunnigle, John Cryan, Rie Matsuzaki, Gabriel S. S. Tofani, Soner Caner Cagun
| Nature Verified
Abstract Planetary and human health including mental health are closely interrelated. Increasing evidence also points to a role for the microbiota-gut-brain axis in maintaining optimum mental health. Emerging evidence raises concerns about the unintended toxicity of environmental exposure to xenobiotics, any substance foreign to the body, on the brain and behavior. Glyphosate is one of the most widely used active ingredients for herbicides for both agricultural and domestic applications.
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Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition

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By Serena Boscaini, Gerard M Moloney, Laila Zeraik, Caroline O’Leary, Aimone Ferri, Elizabeth Schneider, Carina Carbia, Kenneth J. O’Riordan, Nicole Tosi, Daniele Del Rio, Alice Rosi, Letizia Bresciani, Pedro Mena, Gerard Clarke, John Cryan, Thomaz F. S. Bastiaanssen, Federica Bergamo, Maha Irfan, Maaike van der Rhee, Thaïs I. F. Lindemann, Arthi Chinna Meyyappan, Kirsten Berding Harold, Caitríona M. Long-Smith
| Nature Verified
Abstract Coffee influences multiple physiological processes, including gut function, stress, cognition, and the microbiome. However, the mechanisms underlying these effects remain poorly understood. In this study, we examined coffee’s impact on the microbiota–gut–brain axis—a bidirectional communication pathway between the gut microbiome and the brain—and assessed whether these effects occur independently of caffeine in healthy participants.
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Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice - Nature Communications

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By Cristina Cuesta-Marti, Eduardo Ponce-España, Friederike Uhlig, Loreto Olavarría-Ramírez, Benjamin Valderrama, Klara Vlckova, Aonghus Lavelle, Catherine Stanton, R. Paul Ross, John Cryan, Timothy G. Dinan, Gerard Clarke, Siobhain M. O’Mahony, Harriët Schellekens, Iris Stoltenborg, Luiza A. Wasiewska, Lamiah Kareem, Dara Hedayatpour, Cristina Rosell-Cardona, Thomaz. F. S. Bastiaanssen, Gabriel. S. S. Tofani
| Nature Verified
Abstract An unhealthy diet disrupts feeding behavior and the gut microbiota, but whether early-life dietary effects persist, or can be restored later in life, remains unclear. We investigated whether microbiota-targeted interventions (FOS + GOS or Bifidobacterium longum APC1472) could restore early-life high-fat/high-sugar (HFHS) diet-induced feeding alterations in adult female and male mice.
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