John Grigg on Muck Rack

John Grigg

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As seen in: Nature, Wiley Online Library, Sportsnet Canada, Stem Cell Reports, Medical Journal of Australia (MJA), The Hockey News, The Journal of Immunology, Inside Story, The Fulcrum (U.S.), Mivision
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Articles

The quality-of-life impacts and economic burden of X-linked retinitis pigmentosa caused by variants in RPGR

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By Deborah J. Schofield, Joshua Kraindler, Rupendra N Shrestha, Owen Tan, Sarah West, Natalie Hart, Lauren Wall, Alan Ma, John Grigg, Robyn Jamieson, Dustin Hewett, Lorraine Villaret
| Nature Verified
Abstract To estimate the health and societal costs and health-related quality of life (HRQoL) impacts of X-linked retinitis pigmentosa (XLRP) caused by RPGR. Primary data were obtained from a clinical cohort of 9 patients with X-linked retinitis pigmentosa (XLRP) and 4 caregivers. Health-related quality of life (HRQoL) impacts for patients and carers are assessed using utility values derived from the Assessment of Quality of Life–8 Dimension (AQoL-8D) instrument.
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Visual Acuity Alone Is Not Enough: The Need for Multimodal Biomarkers in Dominant Optic Atrophy-Response

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By Christopher A. Ovens, John Grigg, Clare Fraser, Y. Han
| Wiley Online Library Verified
No abstract is available for this article. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1, , , and , “Visual Acuity Alone Is Not Enough: The Need for Multimodal Biomarkers in Dominant Optic Atrophy,” Clinical & Experimental Ophthalmology (2025).
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Connecting cilium, stress response, and proteostasis abnormalities inform variant and therapy assessment in RPGRIP1 retinal organoids

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By Anson Cheng, Hani Kim, Milan Fernando, Benjamin Nash, Nader Aryamanesh, John Grigg, Pengyi Yang, Anai Gonzalez-Cordero, Robyn Jamieson
| Stem Cell Reports Verified
Results We applied TruSight One Clinical Exome sequencing to examine a bioinformatic gene panel of 65 IRD genes, which identified RPGRIP1 variants in 2 patients, LCA-1 and LCA-2, with poor vision and nystagmus manifested in the first 3 months of life. Electroretinograms showed reduced responses, and poor visual acuity was consistent at last review at ages 29 and 27 years for LCA-1 and LCA-2, respectively, with ophthalmic changes characteristic of LCA (Figures S1A and S1B).
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