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John Mandrola

Louisville
As seen in: Sensible Medicine (Podcast), Sensible Medicine Newsletter, This Week in Cardiology, Medium, WebMD, Wiley Online Library, CNBC, Sensible Medicine, Substack, JAMA (The Journal of the American Medical Association), JAMA: Journal of the American Medical Association, Medscape, Medscape Duestch and
Heart rhythm doc, writer for @Medscape, host of This Week in Cardiology podcast, editor of Sensible Medicine. The more you see, the harder medicine gets.
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Articles

Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial

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By John Mandrola
| Medscape Verified
A common teaching in cardiology holds that inflammation plays a causal role in atherosclerotic cardiovascular disease (ASCVD). The recent announcement that the ZEUS cardiovascular outcomes trial of the anti-inflammatory drug ziltivekimab returned null results has seriously challenged this. John M. Mandrola, MD Before ZEUS, the belief that inflammation had a causal role in ASCVD was strong enough for experts to have written a detailed ACC Scientific Statement on the topic.
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Atrial Fibrillation and Symptoms – A Great Mystery

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By John Mandrola
| Sensible Medicine Newsletter
One of the toughest problems in the care of patients with atrial fibrillation (AF) is sorting out symptoms. The tails are easy: some know the second AF starts and they feel awful; others feel nothing when in AF. The largest group of AF patients have some symptoms but whether it correlates with the heart rhythm (regular or not) is hard to know. One of the most common ways we evaluate symptoms from AF is to cardiovert the patient.
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Name an article that changed your practice or how you think about medicine

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By Adam Cifu, John Mandrola
| Sensible Medicine Newsletter
Sensible Medicine is a reader-supported Substack. If you appreciate our work, consider becoming a free or paid subscriber.
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