John McIntyre on Muck Rack

John McIntyre

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Ireland
As seen in: Connacht Tribune, Nature
Sports Editor of the Connacht Tribune and honorary Life President of the sanctuary for worn out and broken down hurling team managers!
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Articles

GPNMB-directed CAR T cell therapy against MiT/TFE-family fusion-driven solid tumors

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By Franz J. Zemp, Hyojin Song, Taye Louie, Hongrui Liu, Yeon Ok Suh, Edna Ayerim Mandujano-Tinoco, Nicolas Collao, Joanna Pyczek, Kristofor K. Ellestad, Cini M. John, Laura K. Mah, Jahanara Rajwani, Danyel Evseev, Madison Turk, Sacha Benaoudia, Jonathan Alex, Victor Naumenko, Varsha Thoppey Manoharan, Harmony Smith, Aaron Gillmor, Hayley M. Todesco, Bo-Young Ahn, Colleen Anderson, Saif Sikdar, Tarek A. Bismar, Daniel Heng, Keith Lawson, W. Marston Linehan, Haley Pedersen, Paul Gordon, John McIntyre Verified, john Mcintyre, John MacGregor, Livia Garzia, Kathy Brodeur-Robb, Travis Ogilvie, Patrick Schöffski, Agnieszka Wozniak, Robert Holt, John Bell, Donna L. Senger, Victor A Lewis, Michael J. Monument, Omar Khan, Lou Baudrier, Pierre Billon, Vincent Gabriel, Jeff Biernaskie, Kiril Trpkov, Kevin Hay Verified, Jennifer Chan, Ramy R. Saleh, Jan Henning, Mona Shafey, A. Sorana Morrissy, Douglas J. Mahoney, Zackariah Breckenridge, Gurveer S. Gill, Kiran Narta, Louisa Guignard, Jada Curry, Jethro Langley, Mobina Kazemi Mehrabadi, Geneece N. Y. Gilbert, Ted B. Verhey, Katalin Osz, Ana Bogossian, Shahrbano Rukunuddin, Lisa DiFrancesco, Kyle Potts, Jennifer Quizi, Nicole L. Prokopishyn
| Nature Verified
Abstract Chimeric antigen receptor (CAR) T cell therapy for solid tumors is constrained by the scarcity of safe, uniformly expressed cell-surface targets. Here we identify glycoprotein NMB (GPNMB)—an MiT/TFE-family fusion-driven protein—as being highly, homogeneously and stably expressed in primary and relapsed alveolar soft-part sarcoma (ASPS) and translocation renal cell carcinoma.
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