John O'Neil

NEW YORK — Texas’s 5.4 million students are returning to school this fall amid the usual scramble for textbooks, lockers and desks. The state is also facing a huge problem of its own creation: how to find, evaluate and properly teach as many as 200,000 students wrongly denied special education or overlooked as it sought to limit spending for the nation’s fastest-growing school population. And then there’s the question of how Texas, under orders from the U.S. government, will pay for it all.

The NLRP3 inflammasome is a central regulator of inflammation in many common diseases, including atherosclerosis and type 2 diabetes, driving the production of pro-inflammatory mediators such as IL-1? and IL-18. Due to its function as an inflammatory gatekeeper, expression and activation of NLRP3 need to be tightly regulated. In this study, we highlight novel post-transcriptional mechanisms that can modulate NLRP3 expression.

Author contributions: MH conceived and coordinated the study and wrote the manuscript. LAJO helped with study design and coordination, interpretation of results and critically revised the manuscript. MH and JDO designed, performed and analyzed experiments. SLM and ARC helped with coordination of experiments and interpretation of results. All authors reviewed the results and approved the final version of the manuscript.