Professor, Mentor, Friend | Genetic Epidemiologist @Stanford
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Articles by John Witte
Leveraging sequences missing from the human genome to diagnose cancer - Communications Medicine
Abstract Cancer diagnosis using cell-free DNA (cfDNA) has the potential to improve treatment and survival but has several technical limitations. In this study, we developed a prediction model based on neomers, DNA sequences 13–17 nucleotides in length that are predominantly absent from the genomes of healthy individuals and are created by tumor-associated mutations. We show that neomer-based classifiers can accurately detect cancer, including early stages, and distinguish subtypes and features.
Unraveling the genetic landscape of susceptibility to multiple primary cancers
1Department of Medicine, University of California, San Francisco, San Francisco, CA, USA 2Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA 3Stanford Cancer Institute, Stanford University, Stanford, CA, USA 4Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA 5Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA 6Helen Diller Family Comprehensive Cancer Center, University...
Rafael DOMINGO, Law and Religion in a Secular Age, The Catholic University of America Press, Washington DC 2024, 332 pp., ISBN 978-0-1323-729-9
Ayuda Buscar en la ayuda Buscar en la ayuda Rafael DOMINGO, Law and Religion in a Secular Age, The Catholic University of America Press, Washington DC 2024, 332 pp., ISBN 978-0-1323-729-9 [1] Emory University Localización: Ius canonicum, ISSN 0021-325X, Vol. 64, Nº 128, 2024, págs. 848-857 Idioma: español Es reseña de: Law and Religion in a Secular Age Rafael DOMINGO Washington DC : The Catholic University of America Press, 2024 Enlaces Texto completo
The PRIMED Consortium: Reducing disparities in polygenic risk assessment
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Keywords polygenic risk score equity diversity Introduction As genomic technologies spur progress in several areas of precision medicine, inequity in translating these advances to diverse groups has become evident.
By Iftikhar J. Kullo, Matthew P. Conomos, Sally N. Adebamowo, Ananyo Choudhury, Stephanie Fullerton, Stephanie M Gogarten, Ben Heavner, Whitney E. Hornsby, Eimear E. Kenny, Alyna khan, Amit V. Khera, Yun Li Verified, Iman K. Martin, Josep M. Mercader, Maggie Ng, Laura M. Raffield, Alex P. Reiner, Robb Rowley, Daniel J. Schaid, Adrienne M. Stilp, Ken Wiley, Riley Wilson, John Witte, Pradeep Natarajan, Clement Adebamowo, Paul L. Auer, Jennifer E. Below, Palwende Romuald Boua, Kristin Boulier, Michael Bowers, Joseph Breeyear, Nilanjan Chatterjee, Tinashe Chikowore, Jaewon Choi, Nancy Cox, Sinead Cullina, Burcu F Darst, Aaron Deutsch, Yi Ding, Todd Edwards, Eleazar Eskin, Segun Fatumo, Jose C. Florez, José Miguel Florez, José Fernando Flórez, Nelson B. Freimer, Tian Ge, Daniel H Geschwind, Chris R. Gignoux, Mark O Goodarzi, Xiuqing Guo, Christopher A. Haiman, Neil A. Hanchard, Scott Hazelhurst, Susan R. Heckbert, Jibril B. Hirbo, Kangcheng Hou, Qinqin Huang, Alicia Huerta, Guoqian Jiang, Katherine Johnston, Linda Kachuri, Takashi Kadowaki, Abram Bunya Kamiza, Sarah L. Kerns, Joohyun Kim, Iain R. Konigsberg, Charles Kooperberg, Matt Kosel, Peter Kraft, Soo-Heon Kwak, Leslie Lange, Loic Le Marchand, Hyunsuk Lee, Aaron Leong, Meng Lin, Kirk E. Lohmueller, Ruth J. F. Loos, Kevin Lu, Alisa Manning, Alicia Martin, Hilary Abom Martin, Rasika A. Mathias, James B Meigs, Rachel Mester, Mariah C. Meyer, Tyne Miller-Fleming, Braxton D. Mitchell, Nicola Mulder, Jie Na, Kristjan Norland, Loes Olde Loohuis, Suna Onengut-Gumuscu, Roel A. Ophoff, Päivi Pajukanta, Bogdan Pasaniuc, Aniruddh Patel, Ulrike Peters, Jimmy Phuong, Michael Preuss, Bruce M. Psaty, Michèle Ramsay, Kenneth Rice, Stephen F. Rich, Jerome I. Rotter, Yunfeng Ruan, Lori C. Sakoda, Philip Schroeder, Jonathan A Shortt, Megan Shuey, Xueling Sim, Roelof A.J. Smit, Johanna Smith, Lucia Sobrin, Daniel O. Stram, Ken Suzuki, Lukasz Szczerbinski, Ran Tao, Bamidele Tayo, Timothy Thornton, Buu Truong, Miriam S. Udler, David van Heel, Luciana B. Vargas, Vidhya Venkateswaran, YING WANG, Jennifer A. Wessel, Laura Wiley, Lynne R Wilkens, Genevieve L Wojcik, Quenna Wong, Toshimasa Yamauchi, Lisa R. Yanek, Yue Stell Yu, Haoyu Zhang, Yuji Zhang, Michael Zhong, Nicholette Allred, Ethan Lange, Ravi Mandia, Ebuka Oneyobi, Bryce Rowan, Siram Sankararaman, Dan Schaid, Dan Schrider, Ruhoilah Shemirani, Lauren Stalbow, Teresa Tusie, David Conti
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The American Journal of Human Genetics
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Principles and methods for transferring polygenic risk scores across global populations - Nature Reviews Genetics
Abstract Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait or disease and may become a valuable tool for advancing precision medicine. However, PRSs that are developed in populations of predominantly European genetic ancestries can increase health disparities due to poor predictive performance in individuals of diverse and complex genetic ancestries.
Development and testing of a polygenic risk score for breast cancer aggressiveness - npj Precision Oncology
Study population The PRS development phase of our study included invasive breast cancers from three datasets with paired germline SNP-tumor gene expression data: the Cancer Genome Atlas (TCGA)21, a publicly available pan-cancer atlas; Molecular Taxonomy of Breast Cancer International Consortium (METABRIC)22, a breast cancer genomic profiling study, and the Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And moLecular analysis 2 (I-SPY 2) TRIAL (NCT01042379)23...
Historical Background on the Religious Test Clause
Article VI, Clause 3: The Senators and Representatives before mentioned, and the Members of the several State Legislatures, and all executive and judicial Officers, both of the United States and of the several States, shall be bound by Oath or Affirmation, to support this Constitution; but no religious Test shall ever be required as a Qualification to any Office or public Trust under the United States.
Constitutional Convention, Ratification, and the Bill of Rights
First Amendment: Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the press; or the right of the people peaceably to assemble, and to petition the Government for a redress of grievances.
The Blessings of Liberty
Leading legal scholar John Witte, Jr. explores the role religion played in the development of rights in the Western legal tradition and traces the complex interplay between human rights and religious freedom norms in modern domestic and international law. He examines how US courts are moving towards greater religious freedom, while recent decisions of the pan-European courts in Strasbourg and Luxembourg have harmed new religious minorities and threatened old religious traditions in Europe.
Education Foundation of Sarasota and Local Businessman Eric Baird to Give $350 to Every Teacher In Sarasota County
Todays News BY JOHN WITTE SRQ DAILY MONDAY BUSINESS EDITION MONDAY DEC 16, 2019 Sarasota County School’s instructional staff, numbering nearly three thousand strong, will receive an unexpected gift this holiday season. The Education Foundation of Sarasota County will administer a $1 million gift from local businessman Eric Baird, in the form of a $350 discretionary grant which may be used for both professional or personal purposes.
Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
Introduction Increasing research into polygenic risk scores (PRSs) for disease prediction highlights their clinical potential for informing screening, therapeutics, and lifestyle. 1 Torkamani A. Wineinger N.E. Topol E.J. The personal and clinical utility of polygenic risk scores. While their use enables risk prediction in individuals of European ancestry, PRSs can have widely varying and much lower accuracy when applied to non-European populations.
Journal of Law and Religion
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Saturday Perspectives Edition
Sign Up for SRQ Daily Advertise in SRQ Daily Send a Letter Submit News [Higher Education] Merger Will Cost New College What Makes It Special Donal O'Shea, doshea@ncf.edu Now in its 60th year, New College is unique within Florida’s state university system. It offers a challenging educational experience that is an ideal fit for exceptional students reaching toward a future as innovative leaders.
Hollywood Doyenne
Heather Graham visits Ringling College of Art and Design, weighs in on sexism in Hollywood, cult movies and more. | By John Witte In People Graham channeling her inner Bond girl, while ready to take on new challenging female characters. Photography by Wyatt Kostygan. Like Marilyn Monroe before her, flaxen-haired movie icon Heather Graham has received a lot of recognition for her on-screen look.
The Course of Heart
Paul Caragiulo enjoys the sunset from a corner of Downtown Sarasota. Photography by Evan Sigmund After making his name in Sarasota's high-pressure restaurant business, Paul Caragiulo had turns in both Sarasota's City and County commisions. Now the longtime resident, family man, amateur singer and pickup-truck enthusiast is back in public life as teh Chair of Sarasota Chamber of Commerce.
Culture City :: SRQ Magazine Article by John Witte
The visionary landscape art of Linda Richichi. SRQ Magazine | January 2020 By John Witte In Visual Arts Linda Richichi Opening Reception, Friday, January 24, 6:00 pm - 9:00 pm at 530 Burns Gallery. Divine inspiration is rarely a happy state. The 10th Century Benedictine nun Hildegard von Bingen experienced what she referred to as “the shade of the living light,” which would plunge her, for days at a time, into a realm of apocalyptic dreams and visions.
DID Restarts the Lights Downtown Program and Proposes Gateway Signage
Todays News BY JOHN WITTE SRQ DAILY FRESHLY SQUEEZED CONTENT EVERY MORNING TUESDAY JAN 7, 2020 The committee overseeing the allocation of funds for the Sarasota Downtown Improvement District (DID) is hoping to bring two major issues before the city commission. The DID was created November 2008, by City ordinance adopted by the Sarasota City Commission at the request of an ad hoc committee of downtown commercial property owners.
Families Joined FabLab for Hands-On Cat Condo Makers Workshop
ROCKETKIDS SRQ DAILY MONDAY BUSINESS EDITION MONDAY DEC 23, 2019 Fifteen family members took do-it-yourself to the next level during the Suncoast Science Center/Faulhaber Fab Lab’s recent Let’s Build: Cat Condo workshop. Armed with a prototype template plus supplies and tools at the ready, families were tasked with building the cat condo of their dreams. Families met over three consecutive Sundays to design, assemble and decorate their new digs using machines available in the Fab Lab.
Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits
Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits Kevin Alexander Hartman, Sara R Rashkin, John S Witte, Ryan D Hernandez bioRxiv 2019.12.18.879916; doi: https://doi.org/10.1101/2019.12.18.879916
Frank Conversations and Surprising Connections Define December's SB2 Luncheon
Business BY JOHN WITTE SRQ DAILY FRESHLY SQUEEZED CONTENT EVERY MORNING TUESDAY DEC 10, 2019 The Hyatt Regency Ballroom is packed, and the crowd is happily mulling around the conference-style roundtables. Nonprofits, donors, activists, workers, and bankers mix company and trade business cards—hardly anyone scans the room for a familiar face to deliver them from an unwanted conversation. SRQ’s Wes Roberts takes the stage and ushers the revelers to their seats.
Journal of Law and Religion
John Witte (a1) (a1) Co-editor, Journal of Law and Religion, Robert W. Woodruff Professor of Law and McDonald Distinguished Professor, Emory University, Director, Center for the Study of Law and Religion View HTML To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account.
Response to the ‘Letter to Calvin parents’
John Witte, Dean of Students|March 14, 2019 Send email to this address Enter Your Name Add a comment here Verification The anonymous author of the guest Op-Ed on March 1 challenged Calvin parents, and perhaps Calvin as an institution, to acknowledge that some students may be sexually active. The author stated that in some circles and conversations, we might pretend this is not true, and perhaps in doing so, miss opportunities to talk about important issues related to sexuality and safety.
Church, State, and Family
This book defends the fundamental place of the marital family in modern liberal societies. While applauding modern sexual freedoms, John Witte, Jr also defends the traditional Western teaching that the marital family is an essential cradle of conscience, chrysalis of care, and cornerstone of ordered liberty. He thus urges churches, states, and other social institutions to protect and promote the marital family.
Personalized Prostate Cancer Screening Based on a Single Midlife Prostate-specific Antigen Measurement
Since May, when the United States Preventive Services Task Force (USPSTF) published its final updated recommendation regarding the use of prostate-specific antigen (PSA) to screen for prostate cancer [1x[1]Grossman, D.C., Curry, S.J., Owens, D.K. et al. Screening for prostate cancer: US Preventive Services Task Force recommendation statement. JAMA. 2018; 319: 1901–1913Google ScholarSee all References][1], the longstanding PSA debate has been reinvigorated.
The Politics of Loopholes
John F. Witte , PhD, is founding dean at the School of Humanities and Social Sciences at Nazarbayev University in Astana, Kazakhstan. He has been a visiting professor in Hungary, Poland, England, Australia, and New Zealand. Witte has authored or coauthored 8 books, including The Politics and Development of the Federal Income Tax , what several reviewers have termed the seminal book on income tax policy and politics, as well as more than 75 articles, book chapters, and reports.
Insurance - Defending LOF - Lloyd's List
Letter to the editor: It is in the industry's interest to help maintain a capable salvage sector Your recent piece on salvage (Marine insurers’ aversion to LOF adds to multiple woes, says Clyde and Co casualty head, 26 May 2017) correctly identifies a number of the challenges facing the marine salvage industry. Indeed, the statistics produced by the International Salvage Union do show a significant reduction in revenue for its members in 2016 (the latest figures available).
Journal of Law and Religion
Theology, the study of God, consists of a network of subdisciplines: biblical theology, moral theology, ecumenical theology, and so on. Each branch of theology has its own distinctive object of study, methods, and purposes. For example, pneumatology studies the Holy Spirit, practical theology uses the pastoral cycle, and liberation theology seeks to transform unjust societal structures that oppress the marginalized. Each branch of theology has its own distinctive community of scholars.
LAW, RELIGION, AND HUMAN RIGHTS IN DAVID LITTLE'S THOUGHT
To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations.
An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations
An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations Arunabha Majumdar, Tanushree Haldar, Sourabh Bhattacharya, John Witte bioRxiv 101543; doi: https://doi.org/10.1101/101543
High-Stakes Choice: Achievement and Accountability in the Nation’s Oldest Urban Voucher Program - John F. Witte, Patrick J. Wolf, Joshua M. Cowen, Deven E. Carlson, David J. Fleming, 2014
Get full access to this article View all access and purchase options for this article. References Barnard J., Frangakis C. E., Hill J. L., Rubin D. B. (2003). Principal stratification approach to broken randomized experiments: A case study of school choice vouchers in New York City. Journal of the American Statistical Association, 98, 299–311. Booher-Jennings J. (2005). Below the bubble: “Educational triage” and the Texas Accountability System. American Educational Research Journal, 42, 231–268. Carlson D.
School Vouchers and Student Attainment: Evidence from a State‐Mandated Study of Milwaukee's Parental Choice Program
1998. “Using Sibling Data to Estimate the Impact of Neighborhoods of Children's Educational Outcomes.” Journal of Human Resources 33 (4): 915–946. , and . 2007. “ The Return on Investment for Improving California's High School Graduation Rate.” Santa Barbara, CA: California Dropout Research Project. , and . 2009. “ High School Dropouts and the Economic Loses from Juvenile Crime in California.” Santa Barbara, CA: California Dropout Research Project. , , , , and . 2006. Does School Choice Work?
The Covariate's Dilemma
Loading metrics Open Access Perspective Joel Mefford, John S. Witte Joel Mefford, John S. Witte Published: November 8, 2012 https://doi.org/10.1371/journal.pgen.1003096 Figures Citation: Mefford J, Witte JS (2012) The Covariate's Dilemma. PLoS Genet 8(11): e1003096. https://doi.org/10.1371/journal.pgen.1003096 Editor: Peter M. Visscher, The University of Queensland, Australia Published: November 8, 2012 Copyright: © 2012 Mefford, Witte.
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