Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Jon Edd
Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications
Keywords circulating tumor cells rare cell technologies cancer metastasis molecular diagnostics liquid biopsy biomarkers tumor heterogeneity minimal residual disease ex vivo cancer models Introduction Genetically targeted therapies and immunotherapies have transformed the treatment of many cancers, but acquired drug resistance and lethal metastatic disease remain a major challenge.
Label‐Free Microfluidic Apheresis of Circulating Tumor Cell Clusters
HeLa Cell Yield and Microfluidic Device Performance For the bulk HeLa cells spiking experiment, 10 µL was taken from each outlet and the number of HeLa cells was counted using disposable hemocytometer slides (Fisher Scientific) under a 4x objective lens. More than 10 views were included. HeLa cell yield was then calculated using the volume fractions of each outlet based on the weight measurement.
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells Avanish Mishra, Taronish D. Dubash, Jon F. Edd, Michelle K. Jewett, Suhaas G. Garre, Nezihi Murat Karabacak, Daniel C. Rabe, Baris R. Mutlu, John R. Walsh, Ravi Kapur, Shannon L. Stott, Shyamala Maheswaran, Daniel A. Haber, Mehmet Toner Proceedings of the National Academy of Sciences Jul 2020, 202006388; DOI: 10.1073/pnas.2006388117
Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes
Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes† Jon F. Edd, ab Avanish Mishra,a Taronish D. Dubash,bc Stefan Herrera, a Ridhwan Mohammad,a E. Kendall Williams,a Xin Hong,b Baris R. Mutlu,a John R. Walsh,ab Fernanda Machado de Carvalho,b Berent Aldikacti, ab Linda T. Nieman,b Shannon L. Stott,abc Ravi Kapur,d Shyamala Maheswaran,bc Daniel A.
Anti-thrombotic strategies for microfluidic blood processing
The redundant mechanisms involved in blood coagulation are crucial for rapid hemostasis. Yet they also create challenges in blood processing in medical devices and lab-on-a-chip systems. In this work, we investigate the effects of both shear stress and hypothermic blood storage on thrombus formation in microfluidic processing. For fresh blood, thrombosis occurs only at high shear, and the glycoprotein IIb/IIIa inhibitor tirofiban is highly effective in preventing thrombus formation.
A Highly-Occupied, Single-Cell Trapping Microarray for Determination of Cell Membrane Permeability
Semi- and selective permeability is a fundamentally important characteristic of the cell membrane. Membrane permeability can be determined by monitoring the volumetric change of cells following exposure to a non-isotonic environment. For this purpose, several microfluidic perfusion chambers have been developed recently. However, these devices only allow the observation of one single cell or a group of cells that may interact with one another in an uncontrolled way.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Jon
Contact Jon, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack