Jonas Karolis Degutis

In the previously published study (Rademaker et al., 2019). two groups of participants completed two VWM experiments where on a given trial they were asked to remember an orientation of a grating, which they had to then recall at the end of the trial. In the first experiment, the delay period was either left blank (no-distractor) or a noise or randomly oriented grating distractor was presented (Figure 1a).

Abstract Although working memory reliably activates the dorsolateral prefrontal cortex (dlPFC), the functional significance of its distinct cytoarchitectonic layers is not well understood in humans. A recent functional magnetic resonance (fMRI) study at 7T demonstrated for the first time layer-specific responses in the human dlPFC during working memory. Superficial layers were more active during the delay period when working memory items needed to be manipulated compared to mere maintenance.

Abstract The dorsolateral prefrontal cortex (dlPFC) is reliably engaged in working memory (WM) and comprises different cytoarchitectonic layers, yet their functional role in human WM is unclear. Here, participants completed a delayed-match-to-sample task while undergoing functional magnetic resonance imaging (fMRI) at ultra-high resolution. We examine layer-specific activity to manipulations in WM load and motor response.