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Articles by Jonathan Du
Caffeine and 4-Hydroxybenzoic Acid Cocrystal Hydrate: Preparation, Characterization, and Evaluation
1 Introduction The concept of cocrystallizing active pharmaceutical ingredients (APIs) with pharmaceutically acceptable coformers has become a preferred crystal engineering technique to control factors such as solubility, dissolution rate, mechanical behavior, and solid-state stability without any change in the covalent structure of the drug molecule [1, 2].
Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease - Nature Communications
Abstract IgG antibodies have a conserved N-linked glycan on residue Asn297 of the homodimeric Fc region that modulates antibody-mediated effector functions. These effects on the immune response are reflected in correlations between IgG glycans and numerous infectious and autoimmune diseases. However, current studies fail to characterize these Asn297-linked glycans comprehensively, relying on glycan release methods.
The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases - Nature Communications
Abstract Corynebacterium diphtheriae clade species secrete single-domain endo-β-N-acetylglucosaminidases (ENGases) that specifically bind to human IgG antibodies and hydrolyze their N297-linked glycans. Here, we define the molecular mechanisms of IgG-specific deglycosylation for the entire family of corynebacterial IgG-specific ENGases, including but not limited to CU43 and CM49.
An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase - Nature Communications
Abstract N-terminal cysteine oxidases (NCOs) act as enzymatic oxygen (O2) sensors, coordinating cellular changes to hypoxia in animals and plants. They regulate the O2-dependent stability of proteins bearing an N-terminal cysteine residue through the N-degron pathway. Despite their important role in hypoxic adaptation, which renders them potential therapeutic and agrichemical targets, structural information on NCO substrate binding remains elusive.
Influence of Halogen Substituents on the Photophysical Properties of 7‐Hydroxycoumarin: Insights from Experimental and Theoretical Studies
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Razones por las que los defectos periodontales verticales son una contraindicación para la técnica del escudo alveolar
Razones por las que los defectos periodontales verticales son una contraindicación para la técnica del escudo alveolar Autores: Jonathan Du Toit, Geoff Patterson Localización: Quintessence: Publicación internacional de odontología, ISSN 0214-0985, Vol. 12, Nº. 1, 2024, págs. 24-35 Idioma: español Texto completo no disponible (Saber más ...) Resumen Se ha publicado mucho sobre la técnica del escudo alveolar desde su introducción en la implantología en 2010.
IJMS | Free Full-Text | Non-Antigenic Modulation of Antigen Receptor (TCR) Cβ-FG Loop Modulates Signalling: Implications of External Factors Influencing T-Cell Responses
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
GH18 ENDO-β-N-ACETYLGLUCOSAMINIDASES USE DISTINCT MECHANISMS TO PROCESS HYBRID-TYPE N-LINKED GLYCANS
Abstract N-glycosylation is one of the most abundant post-translational modifications of proteins, essential for many physiological processes, including protein folding, protein stability, oligomerization and aggregation, and molecular recognition events. Defects in the N-glycosylation pathway cause diseases that are classified as congenital disorders of glycosylation.
Professional Briefing - Trending Commercial and Retail Leasing Topics | Lexology
Click here to watch the video. In this interactive session, the team at Addisons provides an overview of the trending commercial and retail leasing topics, including the following subtopics; rental moratorium and other tenant reliefs; termination of leases due to “frustration”; drafting to entrench lease incentives; and director liability for rent and contingent debts.
COVID-19 Retail and Commercial Leases Regulation Extended - Support Continues for Retail and Commercial Tenants | Lexology
Australia
November 12 2020 In our previous paper we discussed the NSW Government’s announcement that the Retail and Other Commercial Leases (COVID-19) Regulation 2020 (NSW) (COVID-19 Regulation No 1), which was set to end on 25 October 2020, would now be extended to 31 December 2020. To give effect to that extension, the NSW Government has made the Retail and Other Commercial Leases (COVID-19) Regulation (No 2) 2020 (NSW) (COVID-19 Regulation No 2), effective as of 24 October 2020.
About half of University students graduate with debt, report says
Over half of University of Minnesota bachelor's degree recipients graduate with debt, according to a report published by University Government and Community Relations last month. One-third of bachelor’s degree students graduated with an average of $15,952 in debt, according to the report, and nearly one-fourth graduated with an average debt of nearly $35,000.
Red lines "are just political," says Iranian top diplomat
In an interview with "Face the Nation" moderator Margaret Brennan, Iranian Foreign Minister Mohammad Javad Zarif offered his take on the alleged use of chemical weapons by the Syrian regime on civilians in Douma, a rebel stronghold now overtaken by Bashar al-Assad's forces. "Opposition on the use of chemical weapons is crystal clear for everybody. For everybody," Zarif told "Face the Nation" when asked if Iran had told Bashar al-Assad not to use chemical weapons.
Parkland student journalists reflect on reporting the shooting
Ahead of the "March for Our Lives" rally in support of gun control, five student journalists from Marjory Stoneman Douglas High School told "Face the Nation" moderator Margaret Brennan about struggles covering a deadly shooting at their own school. Several of the students described hiding in the photography closet during the shooting. After the students evacuated, some of the students on the high school's newspaper, The Eagle Eye, began reporting.
Fraternities struggle to fill rooms despite increased membership
Hundreds of college students spill from the fraternity houses lining University Avenue on Friday nights. During the week, the houses are emptier than normal. Despite the fact 11 percent of the University of Minnesota’s students participate in Greek life, some Greek houses struggle to attract members to fill their rooms. “It could be personal preference,” said Ronald Atkinson, the Interfraternity Council & National Pan-Hellenic Council advisor for the University.
New magazine upends Asian-American stereotypes
Katerina Jeng and Krystie Mac want to tell you a story. Actually, quite a few stories. They may have been raised on opposite sides of the country, but both grew up aware of the stereotypes they faced as Asian-Americans. For both, it became a passion to help change how ingrained these ideas were. "Being Asian-American, you're not completely Asian, you're not completely American," Jeng said.
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