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Jonathan P Tyrer on Muck Rack

Jonathan P Tyrer

As seen in: Nature, MDPI, BMC Genomics, The American Journal of Human Genetics, medRxiv, Texas Medical Center
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Articles

Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population - British Journal of Cancer

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By Lorenzo Ficorella, Xin Yang, Joe Dennis, Jonathan P Tyrer, Weang-Kee Ho, Mikael Hartman, Jacques Simard, Juliet A. Usher-Smith, Douglas F. Easton
| Nature Verified
Abstract BOADICEA is a widely used algorithm for predicting breast and ovarian cancer risks, using a combination of genetic and lifestyle, hormonal and reproductive risk factors. However, it has largely been developed using data from White/European individuals, limiting its applicability to other ethnicities. Here, we updated BOADICEA to provide ethnicity-specific risk estimates.
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Characterizing somatic mutations in ovarian cancer germline risk regions - Communications Biology

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By Jonathan P Tyrer, Paul Pharoah
| Nature Verified
Abstract Epithelial ovarian cancer (EOC) genetics research has been focused on germline or somatic mutations independently. Emerging evidence suggests that the somatic mutational landscape can be shaped by the germline genetic background. In this study, we aim to unravel the role of somatic alterations within EOC germline susceptibility regions by incorporating functional annotations.
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The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data

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By Naomi Wilcox, Jonathan P Tyrer, Joe Dennis, Xin Yang, Eugene J. Gardner, Douglas F. Easton
| The American Journal of Human Genetics Verified
Keywords heritability genetics cancer rare variants exome burden protein-truncating variants Introduction Genome-wide association studies (GWASs) have been highly successful at identifying common variants associated with disease. Increasingly, association studies are being extended to study rare variants using next-generation sequencing methods.
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