Jongbu Lim

1 Introduction Plants serve as an enduring source of medicinal compounds, many of which have laid the foundation for modern pharmacology. Although advances in chemical synthesis have enabled the large-scale production of complex drugs, many pharmaceuticals still depend on plant specialised metabolites as essential precursors (Newman and Cragg 2016).

Keywords inositol polyphosphate multikinase IPMK CD4+ T cells Th1 cells Th17 cells CD4+ T cell differentiation STAT3 signaling PIP3-Akt-mTOR signaling Leishmania major infection experimental autoimmune encephalomyelitis EAE Research topic(s) CP: Immunology CP: Metabolism Introduction CD4+ T helper (Th) cells not only play critical roles in mediating adaptive immune responses to various pathogens but are also involved in allergic responses, autoimmunity, and tumor immunity.