Joo Yeun Lee

eLife Assessment This study presents a valuable finding on a new role of glia in activity-dependent synaptic remodeling using the Drosophila NMJ as a model system. The evidence supporting the claims of the authors is convincing. The authors have addressed most of the reviewers' concerns and help to further clarify the claims. The work will be of interest to neuroscientists working on glia-neuron interaction and synaptic remodeling.

Abstract Following input loss from degeneration, injury, and/or aging, downstream circuits undergo modifications that can impact fundamental sensory computations. Using the retina to leverage known cell types, well-defined circuitry, and molecular tools, we show how multiple pathways adjust their functional properties differently to common input loss and further locate these changes within each pathway.

Abstract The ability of neurons to rapidly remodel their synaptic structure and strength in response to neuronal activity is highly conserved across species and crucial for complex brain functions. However, mechanisms required to elicit and coordinate the acute, activity-dependent structural changes across synapses are not well understood.