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Jordan Tillinghast on Muck Rack

Jordan Tillinghast

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Articles

Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2

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By Jordan Tillinghast, Sydney Drury, Darren Bowser, Alana Benn
| Cell Press Verified
Highlights • Structures of the Parkinson’s disease-associated polyamine transporter ATP13A2 • Structures of three transport cycle intermediates reveal the gating mechanism • Architecture of the polyamine binding site reveals mechanisms for ion selectivity • The polyamine binding site’s location anticipates an ion channel-like mechanism Summary Mutations in ATP13A2, also known as PARK9, cause a rare monogenic form of juvenile-onset Parkinson’s disease named Kufor-Rakeb syndrome and other...
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