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Jorge Barbazan on Muck Rack

Jorge Barbazan

As seen in: Nature, MDPI, Science Magazine, BioRxiv, Dialnet - Universidad de La Rioja
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Articles

Mecanismos de diseminación y metástasis y abordajes terapéuticos en tumores ginecológicos

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By Luis Alonso Verified, Andrea Arias, Jorge Barbazan, Miguel Abal
| Dialnet - Universidad de La Rioja
Ayuda Buscar en la ayuda Buscar en la ayuda Mecanismos de diseminación y metástasis y abordajes terapéuticos en tumores ginecológicos Luis Gonzalo ALONSO [1] ; Andrea Estrella ARIAS [1] ; Jorge BARBAZAN [1] ; Miguel ABAL [1] [1] Instituto de Investigación Sanitaria de Santiago de Compostela Santiago de Compostela, España Localización: Mol: boletín de la Sociedad de Ciencias de Galicia, ISSN 1133-3669, Nº.
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Friction-induced budding of a cancer cell monolayer

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By Jorge Barbazan, Carlos Gonzalez, Carlos González, Danijela Matic Vignjevic, Mathieu Dedenon
| BioRxiv
Abstract The environment surrounding a tumor plays a crucial role in cancer cell dissemination. Within this microenvironment, cancer-associated fibroblasts (CAFs) generate compressive forces and actively remodel tumors. Using in vitro circular clusters of cancer cell monolayers surrounded by CAFs, we generate structures that are reminiscent of multicellular buds observed in vivo for colo-rectal cancer.
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Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction - Nature Communications

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By Jorge Barbazan, Manuel Gómez-González, Stephanie Descroix, Pierre Sens, Xavier Trepat
| Nature Verified
Abstract During tumor progression, cancer-associated fibroblasts (CAFs) accumulate in tumors and produce an excessive extracellular matrix (ECM), forming a capsule that enwraps cancer cells. This capsule acts as a barrier that restricts tumor growth leading to the buildup of intratumoral pressure.
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