Jorian J. Sepers on Muck Rack

Jorian J. Sepers

As seen in: Nature, Cell Press
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Articles

Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs - Nature Biomedical Engineering

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By Yufeng Li, Limin Zhang, Shengnan Sun, Jorian J. Sepers, Susan L. Kloet, Richard Davis, Joshua J. Gruber, Michael Snyder, XIAO LI, Minkang Tan, Almira Akkari-Henić, Maarten Kip, Harald Mikkers
| Nature Verified
Abstract The functions of non-coding regulatory elements (NCREs), which constitute a major fraction of the human genome, have not been systematically studied. Here we report a method involving libraries of paired single-guide RNAs targeting both ends of an NCRE as a screening system for the Cas9-mediated deletion of thousands of NCREs genome-wide to study their functions in distinct biological contexts.
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