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Jorick Bruins

As seen in: ACS Publications
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Articles

Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry

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By Jorick Bruins, Bauke Bauke Albada, Marloes A. Wijdeven, Ravi V. J
| ACS Publications
Introduction The attachment of functional modalities to monoclonal antibodies (mAbs) is key in the fields of diagnostics,(1) imaging,(2−4) and therapeutics.(4,5) To achieve precisely controlled conjugation, usually a recombinant antibody is subjected to a chemoselective reaction with a functional payload, e.g., an affinity tag,(6) a fluorophore,(7) or a radionuclide.(4) Alternatively, it is attached to a macromolecular structure, e.g., a vesicle, a nanoparticle, a microchip, or a solid...
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Orthogonal, Dual Protein Labeling by Tandem Cycloaddition of Strained Alkenes and Alkynes to ortho-Quinones and Azides

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By Daniel Blanco-Ania, Jorick Bruins, Bauke Bauke Albada
| Royal Society of Chemistry Verified
J. Bruins, D. Blanco-Ania, V. Van der Doef, F. L. van Delft and B. B. Albada, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC02638F If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
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