Marloes A. Wijdeven

Introduction The attachment of functional modalities to monoclonal antibodies (mAbs) is key in the fields of diagnostics,(1) imaging,(2−4) and therapeutics.(4,5) To achieve precisely controlled conjugation, usually a recombinant antibody is subjected to a chemoselective reaction with a functional payload, e.g., an affinity tag,(6) a fluorophore,(7) or a radionuclide.(4) Alternatively, it is attached to a macromolecular structure, e.g., a vesicle, a nanoparticle, a microchip, or a solid...