Josana Kapronezai on Muck Rack

Josana Kapronezai

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Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections - Communications Biology

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By Sebastian Günther, Sven Falke, Julia Lieske, Jure Loboda, Alexander M. Herrmann, Aida Rahmani Mashhour, Aleksandra Usenik, Marcos Bryan Heinemann, Marcin Drag, Tobias Beck, Russell Cox, Henry Chapman, Christian Betzel, Gregor Ebert, Dusan Turk, Carsten Wrenger, Wiebke Ewert, Viviane Fongaro Botosso, Josana Kapronezai, Paula Roberta Giaretta, Winfried Hinrichs
| Nature Verified
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we show that Calpeptin is an extremely potent cysteine cathepsin inhibitor, a finding additionally supported by X-ray crystallography. Cell infection assays proved Calpeptin’s efficacy against SARS-CoV-2.
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