Joseph Gallagher

Abstract Gene editing has the potential to solve fundamental challenges in agriculture, biotechnology, and human health. CRISPR-based gene editors derived from microbes, while powerful, often show significant functional tradeoffs when ported into non-native environments, such as human cells. Artificial intelligence (AI) enabled design provides a powerful alternative with potential to bypass evolutionary constraints and generate editors with optimal properties.

Components of the CCare score and other metrics At the start of the first year, 64% of the patient cohort was within the target for SBP (online supplemental table 1). This increased to 70% at year 4 but reverted to 67% in year 8. Exercise and antiplatelet/anticoagulant treatment showed a similar pattern of improvement up to year 4, with a degree of decline from year 4 to year 8 (table 2). The number of patients with comorbid diabetes that had HbA1c readings within target increased over time.