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Articles by Joshua LaBaer
Genome-wide CRISPR screen identifies mutation-specific pathways converging on TAZ/TEAD activation in mutant p53-driven breast cancer
Abstract Most clinical mutations of TP53 are missense mutations. We previously showed that TP53-missense mutations common in triple-negative breast cancer (TNBC) patients produce neomorphic phenotypes compared to TP53-null cells, with the TAZ/TEAD pathway strongly associated with cell invasion in aggressive p53 mutants. But TP53 mutations alone are insufficient for full oncogenesis. We performed a genome-wide CRISPR screen to identify "co-drivers" of the weakly aggressive p53 mutation, Y234C.
Ultrasensitive and Multiplexed Protein Imaging with Clickable and Cleavable Fluorophores
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Ultrasensitive and multiplexed protein imaging with clickable and cleavable fluorophores
Abstract Single-cell spatial proteomic analysis holds great promise to advance our understanding of the composition, organization, interaction and function of the various cell types in complex biological systems. However, the current multiplexed protein imaging technologies suffer from low detection sensitivity, limited multiplexing capacity or technically demanding.
Autoantibodies in Early Detection of Breast Cancer
CEBP Focus Femina Rauf, Karen S. Anderson and Joshua LaBaer DOI: 10.1158/1055-9965.EPI-20-0331 Published December 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract In spite of the progress made in treatment and early diagnosis, breast cancer remains a major public health issue worldwide.
Autoantibodies in early detection of breast cancer
CEBP Focus Femina Rauf, Karen S Anderson and Joshua LaBaer DOI: 10.1158/1055-9965.EPI-20-0331 Abstract In spite of the progress made in treatment and early diagnosis, breast cancer remains a major public health issue, worldwide. Although modern image-based screening modalities have significantly improved early diagnosis, around 15-20% of breast cancers still go undetected. In underdeveloped countries, lack of resources and cost concerns prevent implementing mammography for routine screening.
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Biochemistry Unable to load video. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. An unexpected error occurred. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. Summary A detailed protocol for the generation of self-assembled human protein microarrays for the screening of kinase inhibitors is presented.
What's in a sample? Increasing transparency in biospecimen procurement methods
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The APC capture: rapid identification of target CD8+ T cell epitopes by flow cytometry
Identifying immunoreactive CTLs by current technologies (cytokine secretion, intracellular cytokine, cytolytic release, ELISPOT, and MHC tetramer assays) is often difficult when probing multiple target antigens. We developed a rapid flow cytometry assay to detect targeted IFN-γ secretion by CD8+ T cells using commonly available reagents. PBMCs were obtained from HLA-A2+ healthy donors, and CD8+ and CD8− fractions were purified.
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