Joshua Rose on Muck Rack

Joshua Rose

Santa Fe
As seen in: Nature, The Journal of Clinical Investigation, Scottsdale Progress, Western Art and Architecture, American Art Collector, Western Art Collector Magazine, Native American Art
Founder, Rose Creative. IG:bookofjoshua
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Articles

MESH1-mediated coenzyme A degradation drives ferroptosis sensitivity and muscle pathology

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By Chao-Chieh Lin, Joshua Rose, Alexander A. Mestre
| The Journal of Clinical Investigation
Abstract CoA facilitates fatty acid synthesis, energy production, gene regulation, and antioxidant function. While CoA biosynthesis is well characterized, the mechanisms governing CoA degradation remain poorly understood. Here, we identify the Metazoan Homolog of SpoT, MESH1, as a CoA phosphatase that dephosphorylates CoA at the 3′ position of the ribose ring to form dephospho-CoA.
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MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation

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By Chao-Chieh Lin, Joshua Rose, Albert Zhang, Anthony J. Mirando, Alexander A. Mestre, Chien-Kuang Ding, Yihan Liao, Ssu-Yu Chen, Yasaman Setayeshpour, Jianli Wu, Zhong Li, Dong Yan, Matthew Hilton, Pei Zhou, Jen-Tsan Ashley Chi
| Nature Verified
Abstract Biological sulfation reactions require 3′-phosphoadenosine-5′-phosphosulfate (PAPS) as the universal sulfate donor. While the biosynthetic pathway of PAPS has been well characterized, the phosphatase degrading PAPS remains unidentified. Here, we discover MESH1 as a PAPS phosphatase that hydrolyzes PAPS into adenosine-5′-phosphosulfate and phosphate. Our crystallographic analysis of the MESH1–PAPS complex confirms PAPS as a bona fide substrate of MESH1.
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Scottsdale's Western Horizons art sale biggest yet

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By Joshua Rose
| Scottsdale Progress Verified
The third annual Western Horizons exhibition and sale, presented by Legacy Galleryin partnership with Western Spirit: Scottsdale Museum of the West, set new benchmarks for both sales and attendance last month. Generating $1.8 million in sales, it marked  the most successful edition of the exhibition to date and underscored the continued strength of the Western art market.
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